ArticleFoods (Basel, Switzerland)2024
Evaluation of Anticancer and Immunomodulatory Effects of Microwave-Extracted Polysaccharide from
Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Marine Food Polysaccharides: Representative Structural Features, Immunomodulatory Effects, and Food Applications.Marine drugs · 2026Review
- Pharmacokinetic Profiling Evaluation ofMarine drugs · 2026Article
- Immune Enhancement of FermentedMolecules (Basel, Switzerland) · 2025Article
- Recent Advances in Marine-Derived Polysaccharide Hydrogels: Innovative Applications and Challenges in Emerging Food Fields.Polymers · 2025Review
- Antitumor Activity ofMarine drugs · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
In recent years, research on active polysaccharides has progressed significantly, particularly regarding their anticancer and immunomodulatory properties. Among these, clam polysaccharides, a type of marine-derived polysaccharide, exhibit notable biological activities, including both anticancer effects and immune modulation. The aims of this study are to investigate the anticancer and immunomodulatory effects of microwave-extracted clam polysaccharide (MCP) in vitro. Cell experiments demonstrated that MCP significantly inhibited both colony formation and migration of HT-29 cells. Furthermore, treatment with MCP led to the downregulation of Bcl-2 gene expression, a reduction in mitochondrial membrane potential, activation of cytochrome C gene and caspase-3 gene, and, finally, the induction of apoptosis in HT-29 cells, implying the involvement of the mitochondrial pathway. Additionally, MCP was found to prompt a phenotypic shift in macrophages from M2 to M1 subtype and from M0 to M1 subtype. MCP also decreased reactive oxygen species (ROS) levels within the cancer cells, thereby augmenting anticancer efficacy through a dual mechanism of immune activation and antioxidant enhancement. These findings suggest that MCPs present significant potential as natural antitumor agents and immunomodulators, especially in the development of functional foods or drugs.
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Registered trials
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