Computational Fluid Dynamic Optimization of Micropatterned Surfaces: Towards Biofunctionalization of Artificial Organs.

Wenxuan He, Aminat M Ibrahim, Abhishek Karmakar, Shivani Tuli, Jonathan T Butcher, James F Antaki

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenxuan HeSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-3255-5057

Aminat M IbrahimMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-5576-3505

Abhishek KarmakarMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-7131-7636

Shivani TuliMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.

Jonathan T ButcherMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-9309-6296

James F AntakiMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-5430-7353

Funding

National Institute of Health HL089456

6 · The paper itself

Abstract

Modifying surface topography to prevent surface-induced thrombosis in cardiovascular implants allows endothelialization, which is the natural thrombo-resistance of blood-contacting surfaces, and is deemed to be the only long-term solution for hemocompatible materials. We adapted a simulation framework to predict platelet deposition on a modified surface and developed an optimization strategy to promote endothelial retention and limit platelet deposition. Under supraphysiological bulk shear stress, a maximum of 79% linear coverage was achieved. This study concludes that the addition of microtrenches promotes endothelial retention and can be improved through the optimal selection of geometric parameters.

Indexed as

endothelial cellshemocompatibilityLVADmechanical devicesmechanical valvesthrombosis

Identifiers

PMID39593752

DOI10.3390/bioengineering11111092

PMCPMC11591438

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.