Evidence map›Paper›PMID 39593404›Full record

Trial reportJournal of bodywork and movement therapies2024

A pilot randomized clinical trial examining the effects of Qigong on inflammatory status and sleep quality in people with Parkinson's disease.

Sanghee Moon, Caio V M Sarmento, Irina V Smirnova, Yvonne Colgrove, Sue-Min Lai, Kelly E Lyons, Wen Liu

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of bodywork and movement therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Unraveling the Effects ofInternational journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sanghee MoonDepartment of Kinesiology, University of New Hampshire, Durham, NH, USA; Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: sanghee.moon@unh.edu.
Caio V M SarmentoDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA; Department of Physical Therapy, California State University, Fresno, CA, USA.
Irina V SmirnovaDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA.
Yvonne ColgroveDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA.
Sue-Min LaiDepartment of Population Health, University of Kansas Medical Center, Kansas City, KS, USA.
Kelly E LyonsDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Wen LiuDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA.

Funding

Assessment of Mind-body Intervention in Patients with PDR21HD094003 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LIU, WEN · 2018 to 2019
$383k
NICHD NIH HHS R21 HD094003
6 · The paper itself

Abstract

backgroundNeuroinflammation contributes to degeneration of neurons in people with Parkinson's disease (PD). The concentrations of inflammatory cytokines, IL-1β, IL-6, and TNF-α, are often increased in people with PD and are associated with various non-motor symptoms. Qigong exercise is a mind-body practice which has been used as a rehabilitation intervention for people with PD. A previous study showed a strong association between sleep quality and inflammatory status. This study investigated the effect of Qigong on inflammatory status in people with PD and explored potential relationships between inflammatory status and sleep quality in this population.

methodsThe study was a randomized controlled trial. A total of 17 participants completed the 12-week intervention (Qigong (n = 8), sham Qigong (n = 9)). Questionnaires were utilized to assess non-motor symptoms, including sleep quality. Inflammatory cytokines were measured by a high sensitivity antibody-based multiplex assay.

resultsAfter the 12-week intervention, a decreasing trend in the concentrations of IL-1β and IL-6 was found in the Qigong group. Moderate to strong correlations were found between changes in IL-1β concentrations and sleep quality.

conclusionInflammation is an important aspect of PD. This study explored the inflammatory status after a mind-body exercise. Further studies need to extend our findings to confirm the effect of Qigong in people with PD.

Indexed as

Parkinson DiseaseQigongSleep QualityAgedCytokinesFemaleHumansInflammationInterleukin-1betaInterleukin-6MaleMiddle AgedPilot ProjectsTumor Necrosis Factor-alphaCytokinesInterleukin-1betaInterleukin-6Tumor Necrosis Factor-alphaInflammationMind–body therapiesParkinson's diseaseQigongSleep

Identifiers

PMID39593404
PMCPMC11602653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.