ArticleCNS neuroscience & therapeutics2024
Dorsal Raphe Serotonergic Neurons-Ventral Tegmental Area Neural Pathway Promotes Wake From Sleep.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state.eLife · 2026Article
- Narcolepsy: immunity, neural circuitry, and brain network reconfiguration.Frontiers in immunology · 2026Review
- Age-Associated Development of Sleep Disturbances inNature and science of sleep · 2026Article
- Sleep and stress as modifiable drivers of Alzheimer's disease.NPJ dementia · 2026Review
- Sleep and circadian rhythm disruptions in animal models of temporal lobe epilepsy.Frontiers in neuroscience · 2026Review
- Decoding serotonin: the molecular symphony behind depression.Frontiers in cellular neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundDorsal raphe nucleus (DRN) serotonergic neurons projecting to the ventral tegmental area (VTA) neural circuit participate in regulating wake-related behaviors; however, the effect and mechanism of which in regulating sleep-wake are poorly understood.
methodsFiber photometry was used to study DRN serotonergic afferent activity changes in the VTA during sleep-wake processes. Optogenetics and chemogenetics were took advantage to study the effects of DRN serotonergic afferents modulating VTA during sleep-wake. In vivo electrophysiology was employed to investigate how VTA neuronal firings were influenced by upregulation of DRN serotonergic afferents during sleep-wake.
resultsWe found that DRN serotonergic afferent activity in the VTA was higher during wake than during NREM and REM sleep. Chemogenetic activation of VTA-projecting DRN serotonergic neurons increased wake, and optogenetic activation of DRN serotonergic terminals in the VTA induced wake during NREM and REM sleep. Furthermore, we found that optogenetic activation of DRN serotonergic terminals in the VTA increased glutamatergic neuronal firing, decreased dopaminergic neuronal firing, but not influenced GABAergic neuronal firing during NREM sleep.
conclusionOur findings provide evidence in understanding the role of DRN serotonergic neurons-VTA neural pathway in regulating sleep-wake, in which dynamic VTA dopaminergic, glutamatergic, and GABAergic neuronal firing changes responded to the wake promoting effect of DRN serotonergic afferents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.