ArticleJournal of cardiovascular imaging2024
Aortic valve sclerosis is not a benign finding but progressive disease associated with poor cardiovascular outcomes.
Article in Journal of cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Association between cardiometabolic index and major adverse cardio-cerebral events and all-cause mortality in patients with degenerative aortic stenosis: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Circulating cytokines as triggers of endothelial dysfunction and sex-specific interstitial cell response in fibrocalcific aortic valve disease.International journal of biological sciences · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
backgroundAortic valve sclerosis (AVS) shares risk factors with atherosclerosis. However, the relationship between AVS progression with cardiovascular (CV) risk has not been researched. This study investigates CV outcomes according to progression of AVS.
methodsThis study included 2,901 patients with AVS (irregular leaflet thickening and peak aortic jet velocity < 2 m/sec) who underwent serial echocardiograms at least 1 year apart during 2011-2020. The primary outcome was defined as CV death, myocardial infarction, stroke, or revascularization.
resultsDuring a median follow-up period of 3.9 years, 439 of 2,901 AVS patients (15.1%) progressed to mild or greater aortic stenosis. Patients with progression were older and more likely to have atrial fibrillation than those without. In a stepwise regression, age (odds ratio [OR] per 1-year increase, 1.04; 95% confidence interval [CI], 1.01-1.07), peripheral artery disease (OR, 9.07; 95% CI, 3.12-26.4), and left ventricular mass index (OR per 1-g/m
conclusionsThe progression to aortic stenosis in AVS patients is an independent risk factor for CV mortality. These findings suggest that patients with AVS progression may benefit from stricter CV risk monitoring.
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