Evidence map›Paper›PMID 39593129›Full record

Trial reportCritical care (London, England)2024

Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial.

Jean-Jacques Rouby, Sébastien Perbet, Jean-Pierre Quenot, Mao Zhang, Pascal Andreu, Mona Assefi, Yuzhi Gao, Romain Deransy, Jie Lyu, Charlotte Arbelot and 12 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02123940 (Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02123940 phase3completednot on this map

Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2014 to 2018Enrolled483ConditionsAdult Patients Ventilated More Than 48 hArmslung ultrasound score
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jean-Jacques RoubyMultidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Sorbonne University, GRC 29, DMU DREAM, Paris, France. jjrouby@invivo.edu.
Sébastien PerbetAdult Intensive Care Unit, Department of Peri-Operative Medicine, University Hospital Estaing, University of Auvergne, Clermont-Ferrand, France.
Jean-Pierre QuenotMédecine Intensive Réanimation, University Hospital Centre Dijon, University of Bourgogne-Franche Comté, Dijon, France.
Mao ZhangDepartment of Emergency Medicine, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Institute of Emergency Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Pascal AndreuMédecine Intensive Réanimation, University Hospital Centre Dijon, University of Bourgogne-Franche Comté, Dijon, France.
Mona AssefiMultidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Sorbonne University, GRC 29, DMU DREAM, Paris, France.
Yuzhi GaoDepartment of Emergency Medicine, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Institute of Emergency Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Romain DeransyMultidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Sorbonne University, GRC 29, DMU DREAM, Paris, France.
Jie LyuCritical Care Medicine Department, Peking University People's Hospital, Beijing, China.
Charlotte ArbelotMultidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Sorbonne University, GRC 29, DMU DREAM, Paris, France.
Youzhong AnCritical Care Medicine Department, Peking University People's Hospital, Beijing, China.
Antoine MonselMultidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Sorbonne University, GRC 29, DMU DREAM, Paris, France.
Xia JingEmergency Department and Emergency/Medical Intensive Care Unit, 1st Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, China.
Philippe GuerciDepartment of Anaesthesiology and Critical Care Medicine, Institut Lorrain du Cœur et des Vaisseaux, University Hospital of Nancy, University of Lorraine, Nancy, France.
Chuanyun QianEmergency Department and Emergency/Medical Intensive Care Unit, 1st Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, China.
Luiz MalbouissonAnesthesiology, Surgical Sciences and Perioperative Medicine, University of São Paulo Hospital das Clinicas, São Paulo, Brazil.
Dominique MorandBiostatistics Unit, Department of Clinical Research and Innovation (DRCI), CHU Clermont-Ferrand, Clermont-Ferrand, France.
Louis PuybassetMultidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Sorbonne University, GRC 29, DMU DREAM, Paris, France.
Emmanuel FutierAdult Intensive Care Unit, Department of Peri-Operative Medicine, University Hospital Estaing, University of Auvergne, Clermont-Ferrand, France.
Jean-Michel ConstantinMultidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Sorbonne University, GRC 29, DMU DREAM, Paris, France.
Bruno PereiraBiostatistics Unit, Department of Clinical Research and Innovation (DRCI), CHU Clermont-Ferrand, Clermont-Ferrand, France.
WIN IN WEAN Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostextubation respiratory failure (PRF) frequently complicates weaning from mechanical ventilation and may increase morbidity/mortality. Noninvasive ventilation (NIV) alternating with high-flow nasal oxygen (HFNO) may prevent PRF.

methodsVentilated patients without chronic obstructive pulmonary disease (COPD) and at high-risk of PRF defined as a lung ultrasound score (LUS) ≥ 14 assessed during the spontaneous breathing trial, were included in a French-Chinese randomised controlled trial. PRF was defined by 2 among the following signs: SpO

resultsTwo hundred and forty patients were randomised and 227 analysed (intervention group = 128 and control group = 99). PRF at H48 was reduced in the intervention group compared to the control group: relative risk 0.52 (0.31 to 0.88), p = 0.01. The benefit persisted at day 7: relative risk 0.62 (0.44 to 0.96), p = 0.02. Weaning failure imposing reconnection to mechanical ventilation was not reduced. In patients who developed PRF and were treated by rescue NIV, reintubation was avoided in 44% of control patients and in 12% of intervention patients (p = 0.008). Other secondary outcomes were not different between groups. From a resource utilisation standpoint, prophylactic NIV alternating with HFNO was more demanding and costly than conventional oxygen with rescue NIV to achieve same clinical outcome.

conclusionsCompared to conventional oxygenation, prophylactic NIV alternating with HFNO significantly reduced postextubation respiratory failure but failed to reduce reintubation rate and mortality in patients without COPD at high risk of extubation failure. Prophylactic NIV alternating with HFNO was as efficient as recue NIV to treat postextubation respiratory failure.

Indexed as

Airway ExtubationUltrasonographyVentilator WeaningAgedFemaleHumansLungMaleMiddle AgedNoninvasive VentilationOxygen Inhalation TherapyPulmonary Disease, Chronic ObstructiveRespiratory InsufficiencyHigh flow nasal oxygenLung ultrasound scoreNoninvasive ventilationPostextubation respiratory failureReintubationWeaning

Identifiers

PMID39593129
PMCPMC11590311

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.