Evidence map›Paper›PMID 39593112›Full record

ArticleFluids and barriers of the CNS2024

Relaxation-exchange magnetic resonance imaging (REXI): a non-invasive imaging method for evaluating trans-barrier water exchange in the choroid plexus.

Xuetao Wu, Qingping He, Yu Yin, Shuyuan Tan, Baogui Zhang, Weiyun Li, Yi-Cheng Hsu, Rong Xue, Ruiliang Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fluids and barriers of the CNS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuetao Wu *State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Qingping He *School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China.
Yu YinDepartment of Chemistry, Zhejiang University, Hangzhou, China.
Shuyuan TanKey Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Baogui ZhangState Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Weiyun LiKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, China.
Yi-Cheng HsuMR Collaboration, Siemens Healthcare, Shanghai, China.
Rong XueState Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. rxue@ibp.ac.cn.
Ruiliang BaiInterdisciplinary Institute of Neuroscience and Technology and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China. ruiliangbai@zju.edu.cn.

Funding

the Ministry of Science and Technology of China 2019YFA0707103the National Key Research and Development Program of China 2022ZD0206000the National Key Research and Development Program of China 2022ZD0211901the National Natural Science Foundation of China 82111530201
6 · The paper itself

Abstract

backgroundThe choroid plexus (CP) plays a crucial role in cerebrospinal fluid (CSF) production and brain homeostasis. However, non-invasive imaging techniques to assess its function remain limited. This study was conducted to develop a novel, contrast-agent-free MRI technique, termed relaxation-exchange magnetic resonance imaging (REXI), for evaluating CP-CSF water transport, a potential biomarker of CP function.

methodsREXI utilizes the inherent and large difference in magnetic resonance transverse relaxation times (T

resultsREXI pulse sequence successfully captured changes in the proton exchange rate (from short-T

conclusionsThis proof-of-concept study demonstrates the feasibility of REXI for measuring trans-barrier water exchange in the CP, offering a promising biomarker for future assessments of CP function.

Indexed as

Choroid PlexusMagnetic Resonance ImagingWaterAcetazolamideAnimalsCerebrospinal FluidMalePhantoms, ImagingRatsRats, Sprague-DawleyAcetazolamideWaterBlood cerebrospinal fluid barrierChoroid plexusContrast-agent-freeMagnetic resonance imagingRelaxation exchange

Identifiers

PMID39593112
PMCPMC11590242

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.