Evidence map›Paper›PMID 39593074›Full record

ReviewBMC medical informatics and decision making2024

Qualitative metrics from the biomedical literature for evaluating large language models in clinical decision-making: a narrative review.

Cindy N Ho, Tiffany Tian, Alessandra T Ayers, Rachel E Aaron, Vidith Phillips, Risa M Wolf, Nestoras Mathioudakis, Tinglong Dai, David C Klonoff

Abstract readReview
In one paragraph

Review in BMC medical informatics and decision making, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Population health management fit lifecycles in analytics.Frontiers in artificial intelligence · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cindy N Ho *Diabetes Technology Society, Burlingame, CA, USA.ORCID 0009-0008-3067-1004
Tiffany Tian *Diabetes Technology Society, Burlingame, CA, USA.ORCID 0009-0003-1417-6445
Alessandra T AyersDiabetes Technology Society, Burlingame, CA, USA.ORCID 0009-0000-3054-3207
Rachel E AaronDiabetes Technology Society, Burlingame, CA, USA.ORCID 0009-0005-5120-2264
Vidith PhillipsSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0009-0006-3832-0634
Risa M WolfDivision of Pediatric Endocrinology, The Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0001-7674-520X
Nestoras MathioudakisSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0210-655X
Tinglong DaiHopkins Business of Health Initiative, Johns Hopkins University, Washington, DC, USA.ORCID 0000-0001-9248-5153
David C KlonoffDiabetes Research Institute, Mills-Peninsula Medical Center, 100 South San Mateo Drive, Room 1165, San Mateo, CA, 94401, USA. dklonoff@diabetestechnology.org.ORCID 0000-0001-6394-6862

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe large language models (LLMs), most notably ChatGPT, released since November 30, 2022, have prompted shifting attention to their use in medicine, particularly for supporting clinical decision-making. However, there is little consensus in the medical community on how LLM performance in clinical contexts should be evaluated.

methodsWe performed a literature review of PubMed to identify publications between December 1, 2022, and April 1, 2024, that discussed assessments of LLM-generated diagnoses or treatment plans.

resultsWe selected 108 relevant articles from PubMed for analysis. The most frequently used LLMs were GPT-3.5, GPT-4, Bard, LLaMa/Alpaca-based models, and Bing Chat. The five most frequently used criteria for scoring LLM outputs were "accuracy", "completeness", "appropriateness", "insight", and "consistency".

conclusionsThe most frequently used criteria for defining high-quality LLMs have been consistently selected by researchers over the past 1.5 years. We identified a high degree of variation in how studies reported their findings and assessed LLM performance. Standardized reporting of qualitative evaluation metrics that assess the quality of LLM outputs can be developed to facilitate research studies on LLMs in healthcare.

Indexed as

Artificial IntelligenceClinical Decision-MakingHumansArtificial IntelligenceChatGPTClinical decision-makingLarge Language ModelMachine learning

Identifiers

PMID39593074
PMCPMC11590327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.