ArticleBMC public health2024
The association between maternal smoking during pregnancy and multimorbidity of non-communicable chronic diseases trajectory in offspring.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Predictors of Quit Attempts and Successful Smoking Abstinence in Pregnancy: An Exploratory Analysis of a Pooled Clinical Trial Dataset.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Trial
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14 authors.
Funding
Abstract
objectivesAlthough a few studies have found that maternal smoke during pregnancy (MSDP) is linked to a range of non-communicable chronic diseases (NCDs) in offspring, its association with the onset, progression, and prognosis of multimorbidity of NCDs (MNCDs) has never been studied. STUDY
designPopulation-based prospective cohort study.
methodA total of 318,122 adults aged 18-87 years who were free of heart disease, stroke, and diabetes at baseline were selected. MNCDs was defined as the coexistence of two or three NCDs, including CVDs (coronary heart disease and stroke), cancer (digest, breast, lung, and urination), diabetes (type 1 and type 2), and CLRD (COPD and asthma). Then we used multi-state model to analyse the impacts of MSDP on the progression of MNCDs in the offspring. Associations between MSDP and transition trajectory were analyzed with results expressed as hazard ratio (HR) and 95% confidence interval (95% CI).
resultsDuring the 70.2 years of follow-up, a total of 112,894 participants developed first NCDs (FNCDs), among whom 28,195 developed MNCDs and 21,452 subsequently died. After adjustment for potential confounders, the MSDP was associated with the transition trajectory from baseline to FNCD (HR = 1.10, 95%CI:1.09-1.11) and from FNCDs to MNCDs (HR = 1.08,95%CI:1.06-1.10). Meanwhile, the MSDP was associated with the transition trajectory from MNCDs to death (HR = 1.07,95%CI:1.03-1.11). Further, these association became more pronounced among the offspring who smoke (HR
conclusionThis study suggested that the MSDP is associated with almost all transition phases of MNCDs development and increases the mortality risk of MNCDs in offspring who smoke, and these transition trajectories can be largely reduced by smoking cessation among offspring.
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