ArticleBMC microbiology2024
Guardians of resistance and virulence: detection of mec, femA, Van, pvl, hlg and spa genes in methicillin and vancomycin-resistant Staphylococcus aureus from clinical and food samples in Southwestern Nigeria.
Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Salt Stress Accelerates Tyrosine Depletion byFoods (Basel, Switzerland) · 2026Article
- Prevalence and genotypic characterization of Methicillin-Resistant Staphylococcus aureus (MRSA) harboring femA and tetM in canine and feline otitis externa.Scientific reports · 2026Article
- Raw milk as a reservoir of multidrug resistant bacteria in Khyber Pakhtunkhwa.BMC microbiology · 2026Article
- Comparative Molecular Characterization of Resistance and Virulence inMicroorganisms · 2026Article
- Prophage typing ofIranian journal of microbiology · 2026Article
- Advances in methods for rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- Prevalence and Characterization of the Antimicrobial Resistance and Virulence Profiles ofAntibiotics (Basel, Switzerland) · 2025Article
- Counteracting methicillin resistant Staphylococcus aureus through novel Citral-Azithromycin combination.Scientific reports · 2025Article
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Abstract
backgroundStaphylococcus aureus strains are highly virulent and associated with an eclectic range of severe nosocomial and community-acquired infections.
objectivesThis study assessed methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA/VRSA) from clinical and ready-to-eat (RTE) food sources, screened for antibiotic resistance; and molecular determinants of antibiotic and virulence genes.
methodsAltogether, 465 clinical and RTE food samples were analyzed via conventional microbiological techniques and S. aureus identification was confirmed by nuc gene detection. Phenotypic screening for methicillin and vancomycin-resistance was by agar-screen cum micro-broth dilution respectively, while antibiotic susceptibility testing was done by the disc-diffusion technique. VanA/vanB/VanC1, femA, mecA/mecC; pvl/hlg and spa gene detection was via Polymerase chain reaction.
resultsPhenotypically, 211 Staphylococcal isolates were recovered, 138 (65.4%) of them carrying the nuc gene - all 138 (100.0%) were VRSA, while 59/138 (42.8%) were MRSA phenotypically. Overall, 114/138 (82.6%), 7/138 (5.1%), and 6/138 (4.3%) of isolates had the femA, mecA, and mecC genes, while van genes were detected in only 3 (2.2%) isolates, with virulence determinants pvl, hlg, and spa gene carriage in 8 (5.8%), 10 (7.2%), and 77 (55.8%) isolates respectively. In all, 11.6% carried resistance-associated genes, 55.8% carried virulence genes, and co-detection of resistance and virulence genes was observed in 12.3%. Overall, 96/138 (69.6%) were multidrug-resistant (MDR), while one strain was extremely drug-resistant (XDR). MAR Indices ≥ 0.2 was observed in 83.3% of isolates.
conclusionThis study highlights virulence levels of MRSA and VRSA circulating strains in Osogbo, contributing to their sustained surveillance, and improving available data for successive epidemiology investigations. This study also reports the occurrence of the mecC gene in S. aureus isolates from RTE foods and human samples in Southwestern Nigeria.
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