ArticleScientific reports2024
Eco-friendly bupropion detection sensor with co-formulated dextromethorphan in AUVELITY tablet and spiked plasma.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Ultrasensitive, green molecularly-imprinted poly(o-phenylenediamine) sensor on pencil graphite for trace ertugliflozin quantification in plasma and tablets.BMC chemistry · 2025Article
- Graphene-cobalt hexacyanoferrate modified sensor doped with molecularly imprinted polymer for selective potentiometric determination of bupropion.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecularly Imprinted Polymers (MIPs) are synthetic materials designed to selectively recognize and bind to specific target molecules. The process of determining Bupropion (BUP) using MIPs involves preparing the MIP, extracting the target molecule, and conducting subsequent analysis. A bio-inspired MIP-based electrochemical sensor was developed to detect BUP, utilizing the specific binding of MIPs to Bupropion molecules, enabling precise and sensitive detection. The combination of molecular imprinting and electrochemistry in this approach allows for the development of a highly reliable and effective sensor specifically designed for BUP detection. In this method, copolymerization conditions were carefully optimized to ensure selectivity and sensitivity in detecting BUP. Different monomers, including o-phenylenediamine, 4-aminophenol, L-dopa, and 1,4-phenylenediamine, were explored, with the best interaction observed for L-dopa and 1,4-phenylenediamine. Consequently, their copolymer was implemented to create selective MIPs through a straightforward electropolymerization process on a disposable pencil graphite electrode (PGE) substrate for BUP detection. The functionality of the copolymer of L-dopa and 1,4-phenylenediamine as an electroactive copolymer in preparing electro-polymerized MIP films was investigated for the first time. This was demonstrated by constructing a novel electrochemical sensor for the selective recognition of BUP in different matrices. The interactions between L-dopa and 1,4-phenylenediamine, used as functional monomers, and the template were studied experimentally using UV spectroscopy. BUP was used as the template, and the copolymer was electrografted onto PGE. The constructed sensor was characterized using cyclic voltammetry (CV), and BUP binding to the MIP cavities was measured indirectly with differential pulse voltammetry (DPV) using a ferrocyanide/ferricyanide redox probe. A linear and repeatable response was displayed by the sensor across a range of 1.0 × 10⁻
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.