Evidence map›Paper›PMID 39592730›Full record

ArticleScientific reports2024

Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case-control study.

Zheng Li, Jie Li, Jie Zhong, Chao Qu, Mingyan Du, Huaping Tian, Haojue Xu, Fang Hao, Lulin Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zheng Li *Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, No. 32, Section 2, West 1St Ring Road, Qingyang District, Chengdu, Sichuan, China.
Jie Li *Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, No. 32, Section 2, West 1St Ring Road, Qingyang District, Chengdu, Sichuan, China.
Jie ZhongOphthalmology department of Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Chao QuOphthalmology department of Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Mingyan DuSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, No. 32, Section 2, West 1St Ring Road, Qingyang District, Chengdu, Sichuan, China.
Huaping TianSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, No. 32, Section 2, West 1St Ring Road, Qingyang District, Chengdu, Sichuan, China.
Haojue XuSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, No. 32, Section 2, West 1St Ring Road, Qingyang District, Chengdu, Sichuan, China.
Fang HaoSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, No. 32, Section 2, West 1St Ring Road, Qingyang District, Chengdu, Sichuan, China.
Lulin HuangSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, No. 32, Section 2, West 1St Ring Road, Qingyang District, Chengdu, Sichuan, China. huangluling@yeah.net.

Funding

Department of Science and Technology of Sichuan Province, China 2021YFS0033Department of Science and Technology of Sichuan Province, China 2022NSFSC0385Department of Science and Technology of Sichuan Province, China 2023NSFSC0591Department of Science and Technology of Sichuan Province, China 2023NSFSC0592Hong Kong Scholars Program XJ2024015National Natural Science Foundation of China 81970839National Natural Science Foundation of China 82171026National Natural Science Foundation of China 82301230the China Postdoctoral Science Foundation 2023M740522the University of Electronic Science and Technology ZYGX2021YGLH214
6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). However, the blood physiological indicators for this eye disease are less reported. Here, we systemically investigated healthy controls, DR patients and DM patients from 2014 to 2022 in Sichuan Provincial People's Hospital (Chengdu, China). We found the leukocyte count, urea, and direct bilirubin in the DR patients were significantly increased (P < 0.001) compared with the controls. The ratios of aspartate aminotransferase/alanine transaminase, total bilirubin, indirect bilirubin, and red cell distribution width were lower in the DR patients than in the controls (P < 0.001). Notably, Red blood cell count (mean [SD] = 4.54 [0.67] 10E12/L, OR = 0.75) was significantly decreased (P < 0.001), and cystatin C level (mean [SD] = 1.42 [1.13] mg/L, OR = 1.90) was significantly increased in the DR patients compared with the controls (P < 0.001). However, these two indicators were not significantly different between the DM patients and the controls (P = 0.87 and P = 0.14, respectively). Our results showed that red blood cell count and cystatin C are specific biomarkers for DR patients.

Indexed as

BiomarkersCystatin CDiabetic RetinopathyAdultAgedCase-Control StudiesErythrocyte CountFemaleHumansMaleMiddle AgedBiomarkersCystatin CBiomarkersCystatin CDiabetes mellitusDiabetic retinopathyRed blood cell count

Identifiers

PMID39592730
PMCPMC11599766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.