Evidence map›Paper›PMID 39592715›Full record

ArticleScientific reports2024

Epigenetic dysregulation of H19/IGF2 in hepatic cells exposed to toxic metal mixtures in vitro.

Yehoon Jo, Eugene Lim, Jihye Park, Keunsoo Kang, Mi-Yeon Shin, Jeong Weon Choi, Sungkyoon Kim, Jaehyouk Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. H19 and IGF2 imprinting from embryogenesis to oncogenesis.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yehoon JoDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
Eugene LimInstitute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
Jihye ParkDepartment of Microbiology, College of Science & Technology, Dankook University, Cheonan, Republic of Korea.
Keunsoo KangDepartment of Microbiology, College of Science & Technology, Dankook University, Cheonan, Republic of Korea.
Mi-Yeon ShinDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
Jeong Weon ChoiDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
Sungkyoon KimDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. ddram2@snu.ac.kr.
Jaehyouk LeeInstitute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. frodo21@snu.ac.kr.

Funding

National Research Foundation of Korea 2020R1A2C2006763
6 · The paper itself

Abstract

Exposure to mixtures of toxic metals is known to cause adverse health effects through epigenetic alterations. Here we aimed to examine the unexplored area of aberrant DNA methylation in the H19/IGF2 domain following combined toxic metal exposure. An in vitro epigenotoxicity assay using the human normal liver epithelial cell line THLE-3 was conducted. When THLE-3 cells were exposed to specific concentrations of either organic arsenic or MeHgCl, an increase in the H19 lncRNA levels and a marked reduction in the IGF2 mRNA levels were observed. In contrast, combined exposures coupled with CdCl

Indexed as

DNA MethylationEpigenesis, GeneticHepatocytesInsulin-Like Growth Factor IIRNA, Long NoncodingArsenicCell LineCpG IslandsGene Expression ProfilingHumansLiverArsenicH19 long non-coding RNAIGF2 protein, humanInsulin-Like Growth Factor IIRNA, Long NoncodingDNA methylationEpigenotoxicityH19/IGF2Mixture exposureToxic metals

Identifiers

PMID39592715
PMCPMC11599747

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.