Evidence map›Paper›PMID 39592659›Full record

ArticleScientific reports2024

A pilot study on nasal wash galactomannan as a surrogate marker for invasive aspergillosis among hematology patients in Thailand.

Natnai Charoonrochana, Natini Jinawath, Pitak Santanirand, Atisak Jiaranaikulwanich, Aruchalean Taweewongsounton, Chavachol Setthaudom, Tananun Tanpaibule, Dootsadeephorn Surin, Pansachee Damronglerd, Wasithep Limvorapitak and 4 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

14 authors.

Natnai CharoonrochanaDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Natini JinawathProgram in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pitak SantanirandDivision of Clinical Microbiology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Atisak JiaranaikulwanichDivision of Clinical Microbiology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Aruchalean TaweewongsountonResearch Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Chavachol SetthaudomDivision of Immunology, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.
Tananun TanpaibuleDepartment of Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
Dootsadeephorn SurinDepartment of Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
Pansachee DamronglerdDivision of Infectious Diseases, Department of Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Wasithep LimvorapitakDivision of Hematology, Department of Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Sirapat RungwittayatiwatDepartment of Medicine, Chao Phraya Abhaibhubejhr Hospital, Prachin Buri, Thailand.
Subencha PinsaiDepartment of Medicine, Chao Phraya Abhaibhubejhr Hospital, Prachin Buri, Thailand.
Pimjai NiparuckDivision of Hematology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Porpon RotjanapanDivision of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd, Bangkok, 10400, Thailand. porpon.rot@mahidol.ac.th.

Funding

Mahidol University 64082
6 · The paper itself

Abstract

Universal antifungal treatment has been recommended among hematology patients during chemotherapy to prevent invasive aspergillosis (IA) in developed countries, but it remains a significant challenge in resource-limited settings. Identifying at-risk individuals could enhance clinical outcomes. A prospective pilot study was conducted at four Thai tertiary care hospitals from April 2021 to January 2023, aiming to assess the correlation and the potential of nasal wash galactomannan (GM) as an IA predictor in hematology patients. It enrolled all patients with acute myeloid leukemia (AML) requiring induction chemotherapy and those admitted for stem cell transplantation (SCT). Nasal wash fluid samples were collected for galactomannan testing and fungal culture to assess Aspergillus spp. colonization before chemotherapy. The study included 34 AML and SCT patients. Among them, 3/34 tested positive for Aspergillus spp. colonization via nasal wash fungal culture. After six months, 18 (52.9%) patients were diagnosed with IA-15/25 patients with AML and 3/9 SCT recipients. The traditional culture did not predict IA, whereas nasal wash fluid galactomannan cutoff value of 0.46 yielded a sensitivity of 40% and a specificity of 80% for predicting probable and possible IA in patients with AML. However, in the subgroup analysis, the test did not reveal any correlation with IA development. More extensive studies are needed to validate the optimal IA risk prediction strategy.

Indexed as

BiomarkersGalactoseLeukemia, Myeloid, AcuteMannansAdultAgedAspergillosisAspergillusFemaleHumansInvasive Fungal InfectionsMaleMiddle AgedPilot ProjectsProspective StudiesStem Cell TransplantationBiomarkersgalactomannanGalactoseMannansAcute myeloid leukemiaGalactomannanHematopoietic stem cell transplantInvasive aspergillosisNasal wash

Identifiers

PMID39592659
PMCPMC11599846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.