ReviewMolecular biomedicine2024
Multidrug resistance in Pseudomonas aeruginosa: genetic control mechanisms and therapeutic advances.
Review in Molecular biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Addition of Selenium to Silver Nanoparticles: An Approach to Enhance Their Antimicrobial and Biological Properties - Systematic Review.Biological trace element research · 2026Pooled it
- Detection of carbapenem resistance mechanisms in difficult-to-treat Pseudomonas aeruginosa clinical isolates from a tertiary care hospital in Egypt.BMC microbiology · 2026Article
- Oxygen-dependent partitioning of acetate assimilation via Acs and AckA-Pta pathways inJournal of bacteriology · 2026Article
- Time-Resolved Electrochemical Surface-Enhanced Resonance Raman Spectroscopy Double-Fingerprint for the Detection ofACS measurement science au · 2026Article
- Article
- Non canonical perspectives on AmpR mediated ampC expression in Gram negative bacteria, with particular emphasis on the potential regulatory purview of FtsZ.World journal of microbiology & biotechnology · 2026Review
- Applicability of Nanopore-only whole-genome sequencing forJournal of clinical microbiology · 2026Article
- Design of Experiment-Assisted Development of Biodegradable Chitosan/Whey Protein Isolate Films as Advanced Pro-Regenerative Wound Dressings.Biomacromolecules · 2026Article
- Environmental effectiveness of the National Action Plan to Contain Antimicrobial Resistance: evidence from Chinese soil.National science review · 2026Article
- Highly Efficient Nitrogen Removal byMicroorganisms · 2026Article
- Levofloxacin Inhalation Solution: Superior Efficacy and Minimized Hepatotoxicity Against Chronic Pseudomonas Aeruginosa-Induced Pulmonary Infection.AAPS PharmSciTech · 2026Article
- Bioorthogonal Click Chemistry for Antibody-Free Profiling of Acetylation, Propionylation, and Butyrylation inACS infectious diseases · 2026Article
- Antibacterial and anti-virulence effects ofMicrobiology spectrum · 2026Article
- Identification of a novel natural compound inhibitor targeting AmpC β-lactamase to combat multidrug-resistantFrontiers in microbiology · 2026Article
- Low levels of the second messenger c-di-GMP enhance tolerance and resistance to meropenem inFrontiers in cellular and infection microbiology · 2026Article
- PK/PD-guided ceftazidime-avibactam dosing for multidrug-resistantFrontiers in pharmacology · 2026Article
- Genomic characterization of high-level efflux pump overexpression in Pseudomonas aeruginosa clones with epidemic potential.Folia microbiologica · 2025Article
- One Health Monitoring of ResistantPathogens (Basel, Switzerland) · 2025Article
- Colistin-Conjugated Selenium Nanoparticles: A Dual-Action Strategy Against Drug-Resistant Infections and Cancer.Pharmaceutics · 2025Article
- E3 ligase MKRN2 destabilizes PPP2CA proteins to inactivate canonical Wnt pathway and mitigates tumorigenesis of clear cell renal cell carcinoma.International journal of biological sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Pseudomonas aeruginosa is a significant opportunistic pathogen, and its complex mechanisms of antibiotic resistance pose a challenge to modern medicine. This literature review explores the advancements made from 1979 to 2024 in understanding the regulatory networks of antibiotic resistance genes in Pseudomonas aeruginosa, with a particular focus on the molecular underpinnings of these resistance mechanisms. The review highlights four main pathways involved in drug resistance: reducing outer membrane permeability, enhancing active efflux systems, producing antibiotic-inactivating enzymes, and forming biofilms. These pathways are intricately regulated by a combination of genetic regulation, transcriptional regulators, two-component signal transduction, DNA methylation, and small RNA molecules. Through an in-depth analysis and synthesis of existing literature, we identify key regulatory elements mexT, ampR, and argR as potential targets for novel antimicrobial strategies. A profound understanding of the core control nodes of drug resistance offers a new perspective for therapeutic intervention, suggesting that modulating these elements could potentially reverse resistance and restore bacterial susceptibility to antibiotics. The review looks forward to future research directions, proposing the use of gene editing and systems biology to further understand resistance mechanisms and to develop effective antimicrobial strategies against Pseudomonas aeruginosa. This review is expected to provide innovative solutions to the problem of drug resistance in infectious diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.