ArticleCell biochemistry and biophysics2025
DDX3X Activates Chondrocyte Pyroptosis to Promote Osteoarthritis Progression.
Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Molecular mediators of motion: RNA-RBP networks in exercise-induced osteoarthritis protection.Frontiers in genetics · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RNA-binding protein DDX3X is associated with several biological processes including inflammation and immunity. However, the role of DDX3X in the pathology of inflammation-related osteoarthritis (OA) remains unclear. This study was to explore the action of DDX3X in the progression of OA as well as the underlying mechanisms by using RNA immunoprecipitation (RIP), Immunohistochemical (IHC) and DDX3X knockout mice, etc. We found that DDX3X expression was upregulated in cartilage tissue of OA patient. The in vitro study also showed upregulation of DDX3X in the inflammatory chondrocytes stimulated by LPS. DDX3X overexpression reduced cell viability by inducing pyroptosis in chondrocytes. Knockdown of DDX3X rescued LPS-induced chondrocytes pyroptosis through regulating NLRP3 signaling. In addition, DDX3X deletion attenuates osteoarthritis in vivo. In conclusion, DDX3X promotes OA progression by regulating chondrocytes pyroptosis via the activation of NLRP3 signaling.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.