Evidence map›Paper›PMID 39592495›Full record

ArticleMedical oncology (Northwood, London, England)2024

Associations between the life's essential 8, genetic risk and breast cancer incidence in premenopausal and postmenopausal women: a prospective study in UK Biobank.

Zengle Zhao, Tongmin Chang, Xinjie Liu, Hao Bai, Zhen Li, Yuan Zhang, Hao Chen, Tongchao Zhang, Yuan Zhang, Ming Lu

Abstract read
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In one paragraph

Article in Medical oncology (Northwood, London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zengle ZhaoSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Tongmin ChangSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Xinjie LiuSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Hao BaiDepartment of Nutrition, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Zhen LiSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Yuan ZhangSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Hao ChenClinical Epidemiology Unit, Qilu Hospital of Shandong University, 107 Wenhua West Road, Jinan, 250012, Shandong, China.
Tongchao ZhangClinical Epidemiology Unit, Qilu Hospital of Shandong University, 107 Wenhua West Road, Jinan, 250012, Shandong, China.
Yuan ZhangSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. zhangyuan@qiluhospital.com.
Ming LuSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. lvming@sdu.edu.cn.

Funding

ECCM Program of Clinical Research Center of Shandong University 2021SDUCRCE001TaiShan Scholars NO.tstp20230654
6 · The paper itself

Abstract

The combined effect of cardiovascular risk factors on breast cancer in women is unknown. The relationship between genetic risk combined with cardiovascular health (CVH) levels and breast cancer has not been confirmed. This study aims to explore the relationship between CVH level based on life's essential 8 (LE8) score and breast cancer risk in women with different menopausal statuses and to estimate further the effect of CVH level combined with genetic susceptibility on breast cancer risk. A total of 118,911 women from UK Biobank were included in the study, including 22,676 premenopausal women and 96,235 postmenopausal women. The association between the CVH level and the risk of breast cancer in women with different menopausal statuses was assessed using the Cox proportional hazards regression models, with the healthiest CVH group as the reference. In addition, risk ratios (HRs) and 95% confidence intervals (95% CIs) for the joint effect of the CVH level and polygenic risk score (PRS) were calculated using the PRS from the UK Biobank. During a mean follow-up period of 13.8 years, we observed 733 cases and 3,645 cases of breast cancer in premenopausal and postmenopausal women, respectively. In premenopausal women, the risk of breast cancer was significantly increased in the intermediate CVH group (HR, 1.28; 95%CI 1.08-1.52) and the low CVH group (HR, 1.44; 95%CI 1.13-1.85). In postmenopausal women, the risk of incidence was also significantly increased in the intermediate CVH group (HR, 1.20; 95%CI 1.07-1.32) and the low CVH group (HR, 1.34; 95%CI 1.17-1.54). In the joint effect analysis, the risk of breast cancer for women in the low CVH group and the high genetic risk group was highest in both premenopausal (HR, 8.26; 95%CI 4.44-15.35) and postmenopausal (HR, 8.10; 95%CI 5.50-11.93) women. Women with lower LE8 scores and higher genetic susceptibility have the higher risk of breast cancer. This suggests that women with lower levels of CVH and higher genetic susceptibility have an increased risk of breast cancer under different menopausal statuses.

Indexed as

Biological Specimen BanksBreast NeoplasmsGenetic Predisposition to DiseasePostmenopausePremenopauseAdultAgedCardiovascular DiseasesFemaleHumansIncidenceMiddle AgedProspective StudiesRisk FactorsUK BiobankUnited KingdomBreast cancerCardiovascular healthLife’s essential 8Polygenic risk score

Identifiers

PMID39592495

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.