Evidence map›Paper›PMID 39592473›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Sarcopenic obesity in survivors of childhood acute lymphoblastic leukemia: prevalence, risk factors, and implications for cancer survivors.

Gargi Das, Kritika Setlur, Manisha Jana, Lakshmy Ramakrishnan, Vandana Jain, Jagdish Prasad Meena, Aditya Kumar Gupta, Sadanand Dwivedi, Rachna Seth

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  7. Article
  8. Metabolic Implications of Childhood Cancer.Current pediatrics reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gargi DasDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, Room 807, A Wing, 8th Floor, Mother and Child Building, New Delhi, 110029, India.
Kritika SetlurDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, Room 807, A Wing, 8th Floor, Mother and Child Building, New Delhi, 110029, India.
Manisha JanaDepartment of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
Lakshmy RamakrishnanDepartment of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Vandana JainDivision of Pediatric Endocrinology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Jagdish Prasad MeenaDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, Room 807, A Wing, 8th Floor, Mother and Child Building, New Delhi, 110029, India.
Aditya Kumar GuptaDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, Room 807, A Wing, 8th Floor, Mother and Child Building, New Delhi, 110029, India.
Sadanand DwivediDepartment of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Rachna SethDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, Room 807, A Wing, 8th Floor, Mother and Child Building, New Delhi, 110029, India. drrachnaseth1967@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSarcopenic obesity, characterized by increased adiposity with low skeletal muscle mass, contributes to frailty and the development of chronic disease. Data on sarcopenic obesity in survivors of childhood acute lymphoblastic leukemia (cALL) is limited. METHODOLOGY: A cross-sectional study on 65 cALL survivors (7-18 years, > 2 years from treatment completion) was conducted on cALL survivors with the primary outcome to determine the prevalence of sarcopenic obesity. Sarcopenic obesity was defined as patients with a positive Fat Mass Index (FMI) z-score with a negative Skeletal Muscle Index (SMI) z-score, measured using a Dual-Energy Xray Absorptiometry (DXA) scan. In addition, we assessed the factors associated with sarcopenic obesity by multivariable regression analysis.

resultsThe mean (± SD) age was 12.9 (± 3.2) years, the median (Interquartile Range) time since diagnosis was 6.5 (5.9;8) years, and 66% received cranial radiotherapy. Central obesity, insulin resistance, and metabolic syndrome were seen in 21.5%, 23.1%, and 21% respectively. DXA-derived body composition variables revealed higher fat percentage despite normal body mass index (BMI) and lower muscle mass compared to the general population. Sarcopenic obesity was seen in 21 (34%) of survivors. On multivariable regression analysis, age at diagnosis (OR: 0.95 (95% CI: 0.92-0.98), p = 0.02), central obesity (OR: 18.99 (95% 2.32-155.5), p = 0.006) and insulin resistance (OR: 10.2 (95% CI: 1.75-59.09), p = 0.01) were associated with sarcopenic obesity.

conclusionsSarcopenic obesity, an early clinical indicator for metabolic disease despite normal BMI, was significantly worse in children diagnosed with ALL at a younger age and was associated with central obesity and insulin resistance, which may contribute to adverse outcomes later in life.

Indexed as

Absorptiometry, PhotonCancer SurvivorsObesityPrecursor Cell Lymphoblastic Leukemia-LymphomaSarcopeniaAdolescentBody CompositionChildCross-Sectional StudiesFemaleHumansInsulin ResistanceMalePrevalenceRisk FactorsAcute lymphoblastic leukemiaAdipositySarcopenic obesitySurvivor

Identifiers

PMID39592473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.