Evidence map›Paper›PMID 39592458›Full record

ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2024

Vanadium complexes as potential metal-based antimicrobial drugs.

Meena Kumari, Maridula Thakur, Sonika Sharma, Mala Sharma, Vineet Kumar Choudhary, Reena Sharma, Shubham Sharma, Shalima Kumari, Sachin Kumar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meena KumariDepartment of Chemistry, Himachal Pradesh University, Summer Hill, Shimla, Himachal Pradesh, 171005, India.
Maridula ThakurDepartment of Chemistry, Himachal Pradesh University, Summer Hill, Shimla, Himachal Pradesh, 171005, India. mriduthakur82@gmail.com.
Sonika SharmaDepartment of Chemistry, MLSM College, Sunder Nagar, Chaterokhri, Himachal Pradesh, India.
Mala SharmaDepartment of Chemistry, Sidharth Government College, Nadaun, Himachal Pradesh, India.
Vineet Kumar ChoudharyDepartment of Chemistry, Shree Jagdish Prasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India.
Reena SharmaDepartment of Chemistry, ABVGIET, Pragatinagar, Shimla, Himachal Pradesh, India.
Shubham SharmaDepartment of Chemistry, Himachal Pradesh University, Summer Hill, Shimla, Himachal Pradesh, 171005, India.
Shalima KumariDepartment of Chemistry, Himachal Pradesh University, Summer Hill, Shimla, Himachal Pradesh, 171005, India.
Sachin KumarDepartment of Chemistry, Himachal Pradesh University, Summer Hill, Shimla, Himachal Pradesh, 171005, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radical increase of antibiotic resistance among microbes has become a serious problem for clinics all over the world that has led to the need for search of novel types of antimicrobial drugs. Each year, researchers synthesize a multitude of compounds in pursuit of identifying potential chemotherapeutic agents through diverse methodological evaluations. Among the vast array of biologically significant compounds, coordination compounds exhibit a broad range of activities within biological systems. Chelation, in particular, induces significant alterations in the biological properties of ligands and the metal component, contributing to their efficacy. Chelation increases the lipophilicity of metal complexes as a result of which they are easily absorbed by the microorganisms, thus leading to their easy passage across cell membrane. The research and development in the field of metallodrugs can be advantageous to overcome the problem encountered in antibiotic resistance. The multifaceted involvement of vanadium relative to other biometals within biological systems, coupled with its comparatively lower toxicity, underscores its utility in the advancement of novel metal-based therapeutic agents. This review aims to delineate the biological significance of V(V/IV/III) complexes as antimicrobial agents. The amassed data indicate a correlation between the potency of vanadium complexes as antimicrobial agents and the oxidation state of the metal, with III being the least toxic and V representing the most toxic oxidation state of vanadium.

Indexed as

Coordination ComplexesVanadiumAnimalsAnti-Bacterial AgentsAnti-Infective AgentsBacteriaHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAnti-Infective AgentsCoordination ComplexesVanadiumAntibacterial and antifungal activitiesAntibiotic resistanceAntimicrobial agentsStructure–activity relationshipV(V/IV/III) Complexes

Identifiers

PMID39592458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.