Evidence map›Paper›PMID 39592427›Full record

ArticleFEBS open bio2025

Alcohol induces α2-6sialo mucin O-glycans that kill U937 macrophages mediated by sialic acid-binding immunoglobulin-like lectin 7 (Siglec 7).

Pi-Wan Cheng, Vishwanath-Reddy Hothpet, Ganapati Bhat, Kristina Bailey, Lei Li, Derrick R Samuelson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pi-Wan ChengDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0000-0002-8624-2865
Vishwanath-Reddy HothpetDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Ganapati BhatDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Kristina BaileyDepartment of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Lei LiDepartment of Chemistry and Center for Diagnostic & Therapeutics, Georgia State University, Atlanta, GA, USA.
Derrick R SamuelsonDepartment of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

Funding

Temple Project 1: Genetic characterization of factor VIII Inhibitors and glydosylation patternsU54HL142019 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI LEI, LI · 2018 to 2022
$6.9M
A Comprehensive 5K Plus Glycan MicroarrayR44GM123820 · NIGMS · Z BIOTECH, LLC · PI LI, LEI, ZHANG, JIAN · 2021 to 2023
$1.9M
Mucociliary clearance in agingR01AG053553 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAILEY, KRISTINA L · 2016 to 2020
$1.5M
Mechanisms by Which Alcohol-Induced Dysbiosis Impairs Host Defense Against Klebsiella PneumoniaeR00AA026336 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SAMUELSON, DERRICK R · 2019 to 2021
$743k
BLRD VA I01 BX000985BLRD VA I01 BX006049NHLBI NIH HHS U54 HL142019NIAAA NIH HHS R00 AA026336NIA NIH HHS R01 AG053553NIGMS NIH HHS R44 GM123820US Department of Veterans Affairs 1I1 BX000985US National Institutes of Health 1R00AA026336US National Institutes of Health R44GM123820US National Institutes of Health RO1AG53553US National Institutes of Health U54HL142019US NE Department of Human Health Services 26753
6 · The paper itself

Abstract

Alcohol misuse increases infections and cancer fatalities, but mechanisms underlying its toxicity are ill-defined. We show that alcohol treatment of human tracheobronchial epithelial cells leads to inactivation of giantin-mediated Golgi targeting of glycosylation enzymes. Loss of core 2 N-acetylglucosaminyltransferase 1, which uses only giantin for Golgi targeting, coupled with shifted targeting of other glycosylation enzymes to Golgi matrix protein 130-Golgi reassembly stacking protein 65, the site normally used by core 1 enzyme, results in loss of sialyl Lewis x and increase of sialyl Lewis a and α2-6sialo mucin O-glycans. The α2-6sialo mucin O-glycans induced by alcohol cause death of U937 macrophages mediated by sialic acid-binding immunoglobulin-like lectin 7. These results provide a mechanistic insight into the cause of the toxic effects of alcohol and might contribute to the development of therapies to alleviate its toxicity.

Indexed as

MacrophagesMucinsPolysaccharidesEthanolGlycosylationGolgi ApparatusHumansSialic Acid Binding Immunoglobulin-like LectinsU937 CellsEthanolMucinsPolysaccharidesSialic Acid Binding Immunoglobulin-like LectinsethanolgiantinSiglec 7U937 macrophagesα2‐6sialo mucin O‐glycans

Identifiers

PMID39592427
PMCPMC11705458

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.