Evidence map›Paper›PMID 39592090›Full record

ReviewJournal of molecular and cellular cardiology2025

Leukocyte-lymphatic intersections during cardiac inflammation.

Kristofor Glinton, Abhishek V Thakkar, Rebecca Jones, Hiroyasu Inui, Zhi-Dong Ge, Edward B Thorp

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Immunometabolism in heart failure.Nature reviews. Cardiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristofor GlintonFeinberg School of Medicine, Department of Pathology, Northwestern University, Chicago, IL 60611, United States of America.
Abhishek V ThakkarFeinberg School of Medicine, Department of Pathology, Northwestern University, Chicago, IL 60611, United States of America.
Rebecca JonesFeinberg School of Medicine, Department of Pathology, Northwestern University, Chicago, IL 60611, United States of America.
Hiroyasu InuiFeinberg School of Medicine, Department of Pathology, Northwestern University, Chicago, IL 60611, United States of America.
Zhi-Dong GeThe Heart Center and Cardiovascular-Thoracic Surgery, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Ill, United States of America.
Edward B ThorpFeinberg School of Medicine, Department of Pathology, Northwestern University, Chicago, IL 60611, United States of America. Electronic address: ebthorp@northwestern.edu.

Funding

TRAINING PROGRAM IN IMMUNOLOGY &MOLECULAR PATHOGENESIST32AI007476 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Edward Benjamin Thorp · 1996 to 2026
$6.6M
Efferocytosis-Directed Inflammation Resolution and Repair in the Hypoxic HeartR01HL122309 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THORP, EDWARD BENJAMIN · 2014 to 2024
$5.0M
NHLBI NIH HHS R01 HL122309NIAID NIH HHS T32 AI007476
6 · The paper itself

Abstract

Advances in genetic, pharmacologic, and sequencing technology have led to new insight into the role of lymphatics in health and disease. This includes fundamental aspects of the crosstalk between immune cells with cardiac lymphatics. At the interface between leukocytes and lymphatic endothelial cells, myeloid populations are sources of lymphatic growth factors during inflammation. Lymphatic endothelial cells also secrete signals that activate leukocytes, including to antigen presenting cells. Taken together, a view of the lymphatic vasculature as a supplemental cardiac immune hub is emerging. Herein, we discuss reciprocal cell and molecular crosstalk between leukocytes and lymphatics in the myocardium, with implications for health and cardiac inflammation.

Indexed as

Endothelial CellsLeukocytesLymphatic VesselsMyocarditisAnimalsHumansMyocardiumLymphatic endothelial cellMacrophageMyocardial infarction

Identifiers

PMID39592090
PMCPMC11717605

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.