Evidence map›Paper›PMID 39592089›Full record

ArticleBrain research2025

Response of parvalbumin interneurons and perineuronal nets in rat medial prefrontal cortex and lateral amygdala to stressor controllability.

Brittani Wallsten, Abigail H Gligor, Angela E Gonzalez, Jonathan D Ramos, Michael V Baratta, Barbara A Sorg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brittani WallstenR.S. Dow Neurobiology, Legacy Research Institute, Portland, OR 97232, United States.
Abigail H GligorR.S. Dow Neurobiology, Legacy Research Institute, Portland, OR 97232, United States.
Angela E GonzalezR.S. Dow Neurobiology, Legacy Research Institute, Portland, OR 97232, United States; Integrative Physiology and Neuroscience, Washington State University, Pullman, WA 99164, United States; Program in Neuroscience, Washington State University, Vancouver, WA 98686, United States.
Jonathan D RamosR.S. Dow Neurobiology, Legacy Research Institute, Portland, OR 97232, United States.
Michael V BarattaDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, 80301, United States.
Barbara A SorgR.S. Dow Neurobiology, Legacy Research Institute, Portland, OR 97232, United States; Integrative Physiology and Neuroscience, Washington State University, Pullman, WA 99164, United States; Program in Neuroscience, Washington State University, Vancouver, WA 98686, United States. Electronic address: bsorg@downeurobiology.org.

Funding

Stressor Controllability: The Role of the mPFC in Producing ResiliencyR01MH050479 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI MICHAEL V BARATTA, STEVEN F MAIER · 1993 to 2026
$7.9M
Cocaine, Parvalbumin, and Perineuronal NetsR01DA055645 · NIDA · LEGACY EMANUEL HOSPITAL AND HEALTH CENTER · PI SUE A AICHER, Travis Eugene Brown · 2023 to 2026
$2.9M
STRESSOR CONTROLLABILITY: ANXIETY AND SEROTONINR37MH050479 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI MAIER, STEVEN F · 1997 to 2006
$2.3M
Perineuronal nets and cocaine-associated memoriesR01DA040965 · NIDA · WASHINGTON STATE UNIVERSITY · PI BROWN, TRAVIS EUGENE, SORG, BARBARA A · 2016 to 2020
$2.0M
NIDA NIH HHS R01 DA040965NIDA NIH HHS R01 DA055645NIMH NIH HHS R01 MH050479NIMH NIH HHS R37 MH050479
6 · The paper itself

Abstract

Behavioral control over a stressor limits the impact of the stressor being experienced and produces enduring changes that reduce the effects of future stressors. In rats, these stress-buffering effects of control (escapable stress, ES) require activation of the medial prefrontal cortex (mPFC) and prevent the typical amygdala-dependent behavioral outcomes of uncontrollable stress (inescapable stress, IS). Parvalbumin (PV) interneurons regulate output of excitatory neurons, and most mPFC PV neurons are surrounded by perineuronal nets (PNNs), which regulate firing. We exposed male rats to a single session of ES, IS, or no stress and measured c-Fos expression within PV/PNN-containing cells in mPFC subregions (prelimbic, PL; infralimbic, IL) and in the lateral amygdala. We also measured the number and intensity of PNNs. Within PL and IL PV/PNN cells, both ES and IS increased c-Fos intensity in PV/PNN, non-PV, and non-PNN cells. Within the IL, only ES increased the number of c-Fos-expressing PV/PNN-labeled cells. In the lateral amygdala, only ES increased c-Fos intensity within PV cells and PV/PNN cells. Thus, PV neurons in the IL and lateral amygdala may represent an important substrate by which behavioral control buffers against the amygdala-dependent behavioral outcomes typically observed after uncontrollable stress.

Indexed as

InterneuronsParvalbuminsPrefrontal CortexProto-Oncogene Proteins c-fosRats, Sprague-DawleyStress, PsychologicalAmygdalaAnimalsBasolateral Nuclear ComplexMaleNerve NetRatsParvalbuminsProto-Oncogene Proteins c-fosAmygdalaMedial prefrontal cortexParvalbuminPerineuronal netsResilienceStress

Identifiers

PMID39592089
PMCPMC12667610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.