Evidence map›Paper›PMID 39591643›Full record

ArticleThe American journal of tropical medicine and hygiene2025

Malaria, Dengue Fever, and Leptospirosis in the Urabá Antioqueño Region, Colombia: Etiological and Molecular Characterization among Patients with Acute Undifferentiated Febrile Illness.

Nicaela Restrepo-López, Carlos Ramiro Silva-Ramos, Juan David Rodas, Margarita Arboleda, Diana Fernández, Pablo Uribe-Restrepo, Piedad Agudelo-Flórez, Alberto Tobón-Castaño, Marylin Hidalgo, Peter C Melby and 4 more

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Microorganisms · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicaela Restrepo-LópezGrupo de Investigación en Ciencias Veterinarias Centauro, Universidad de Antioquia, Medellín, Colombia.
Carlos Ramiro Silva-RamosGrupo de Enfermedades Infecciosas, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.
Juan David RodasGrupo de Investigación en Ciencias Veterinarias Centauro, Universidad de Antioquia, Medellín, Colombia.
Margarita ArboledaInstituto Colombiano de Medicina Tropical, Universidad CES, Medellín, Colombia.
Diana FernándezGrupo de Investigación en Ciencias Veterinarias Centauro, Universidad de Antioquia, Medellín, Colombia.
Pablo Uribe-RestrepoGrupo de Investigación en Ciencias de la Vida y de la Salud, Escuela de Graduados, Universidad CES, Medellín, Colombia.
Piedad Agudelo-FlórezGrupo de Investigación en Ciencias de la Vida y de la Salud, Escuela de Graduados, Universidad CES, Medellín, Colombia.
Alberto Tobón-CastañoGrupo de Malaria, Universidad de Antioquia, Medellín, Colombia.
Marylin HidalgoGrupo de Enfermedades Infecciosas, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.
Peter C MelbyDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Patricia V AguilarCenter for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas.
Miguel M CabadaDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Francisco J DíazGrupo de Inmunovirología, Universidad de Antioquia, Medellín, Colombia.
Special Recognition of the Members of the Global Infectious Diseases Research Network (GIDRN)

Funding

Research Training Program on the Impact of Zoonotic and Vector-borne Viruses, Rickettsiae, and Leptospira in Acute Undifferentiated Febrile IllnessesD43TW010331 · FIC · UNIVERSITY OF TEXAS MED BR GALVESTON · PI AGUILAR, PATRICIA VERONICA, RODAS, JUAN DAVID · 2016 to 2025
$2.6M
FIC NIH HHS D43 TW010331
6 · The paper itself

Abstract

Acute undifferentiated febrile illness (AUFI) is the main cause of medical attention in the tropics worldwide. Malaria, arboviral diseases, and leptospirosis are the most important etiologies. These are highly endemic in the Urabá antioqueño, Colombia, being the main causes of fever in several municipalities in this region. However, up-to-date data regarding the infecting species and serotypes are lacking. Thus, we characterized the etiology of AUFI, focusing on malaria, arboviruses, and leptospirosis in this region and the circulating infecting species. An active surveillance was conducted between January and April 2022, and July and October 2023 in two local hospitals in the Urabá antioqueño. Febrile patients were enrolled voluntarily. Malaria, arboviral diseases, and leptospirosis were screened through direct, serological, molecular, and rapid diagnostic methods. Amplicons obtained for dengue virus (DENV) and Leptospira spp. were analyzed through phylogenetic analysis. A total of 184 febrile patients were enrolled. A confirmed etiology was detected in 43.4% of patients from Apartadó and 61.2% from Turbo. Malaria was the most frequent cause in both municipalities, which was caused mainly by Plasmodium falciparum in Apartadó and Plasmodium vivax in Turbo. Dengue virus serotype 1 genotype V, DENV genotype Asian-American, and DENV genotype Cosmopolitan were identified, as well as pathogenic Leptospira species closely related to Leptospira santarosai and Leptospira noguchii. The present study confirms the importance of malaria, dengue fever, and leptospirosis in the Urabá antioqueño. Plasmodium falciparum and P. vivax were identified, as well as two DENV serotypes and three DENV genotypes and two different Leptospira species.

Indexed as

DengueFeverLeptospirosisMalariaAdolescentAdultAgedChildChild, PreschoolColombiaDengue VirusFemaleHumansLeptospiraMaleMiddle Aged

Identifiers

PMID39591643
PMCPMC11803665

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.