ArticleJournal of addiction medicine
New Alcohol-related Condition Diagnoses Are Associated With Opioid Tapers Among Patients Receiving Long-term Opioid Therapy.
Article in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Breaking the Stigma: Integrating Substance Use Disorder Treatment into Primary Care.Missouri medicineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesThe study sought to describe the association between alcohol-related conditions (ARCs) and long-term opioid therapy (LTOT) dose trajectories among patients with chronic pain. We explored if ARCs moderated the association between LTOT tapers and mortality.
methodsWe conducted a retrospective cohort study of 3912 patients receiving LTOT. The association of ARCs before initiating LTOT with subsequent LTOT dose trajectories (increasing, decreasing, stable) was assessed using multinomial regression models. The association of LTOT trajectories with subsequently diagnosed new (incident) ARC was assessed using competing risks regression models. Lastly, we explored whether ARCs moderated the association between LTOT trajectories and all-cause mortality using Cox-proportional hazards models.
resultsOverall, 6.2% (n = 244) of patients receiving LTOT were diagnosed with an ARC prior to initiating LTOT. There was no association between an ARC prior to LTOT initiation with subsequent LTOT trajectory. Among patients without an ARC diagnosis before initiating LTOT, newly diagnosed ARCs were made in 1.3% (n = 50) of patients. Patients in the decreasing LTOT trajectory were twice as likely to be diagnosed with new ARCs compared to those in the stable LTOT trajectory (adjusted hazard ratio, 2.23 [95% CI, 1.15-4.29]). The presence of ARCs did not significantly moderate the relationship between LTOT trajectories and mortality risk.
conclusionsPatients in the decreasing LTOT trajectory are at a higher risk of developing a new ARC. Implementing routine alcohol use screening among patients with LTOT taper would enable early identification for alcohol use. Interventions to reduce alcohol use may mitigate harms associated with LTOT taper.
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Registered trials
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