Evidence map›Paper›PMID 39591285›Full record

ArticleTropical medicine and infectious disease2024

Severity of Vessel Color Changes and Macular and Peripheral Whitening in Malarial Retinopathy Are Associated with Higher Total Body and Sequestered Parasite Burdens.

Chiadika Nwanze, Daniel Muller, Priscilla Suleman, Mrinmayee Takle, John R Barber, Kyle J Wilson, Nicholas A V Beare, Karl B Seydel, Douglas G Postels

Abstract read
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In one paragraph

Article in Tropical medicine and infectious disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chiadika NwanzeDepartment of Pediatrics, Children's National Hospital, Washington, DC 20010, USA.
Daniel MullerGeorge Washington School of Medicine and Health Sciences, Washington, DC 20052, USA.
Priscilla SulemanBlantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.
Mrinmayee TakleDivision of Neurology, Children's National Hospital, Washington, DC 20010, USA.ORCID 0000-0002-5249-7552
John R BarberDivision of Biostatistics and Study Methodology, Children's National Hospital, Washington, DC 20010, USA.
Kyle J WilsonDivision of Neurology, Children's National Hospital, Washington, DC 20010, USA.ORCID 0000-0003-0151-7530
Nicholas A V BeareDepartment of Eye & Vision Science, University of Liverpool, Liverpool L7 8TX, UK.ORCID 0000-0001-8086-990X
Karl B SeydelBlantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.
Douglas G PostelsBlantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.ORCID 0000-0001-5815-0691

Funding

Children's National Hospital NoneThe George Washington University None
6 · The paper itself

Abstract

Two-thirds of children with cerebral malaria (CM) exhibit retinopathy characterized by whitening, vessel color changes, and/or hemorrhages. The pathogenesis of malarial retinopathy is not fully understood. This study aimed to assess the relationship between malarial retinopathy and the severity of its components (macular whitening, retinal hemorrhages, and vessel color changes) with the total, circulating, or sequestered parasite load in children with CM. Total parasite burden was estimated by measuring plasma levels of Plasmodium falciparum histidine-rich protein 2 (PfHRP2), while the sequestered load was calculated as the difference between the total burden and circulating parasitemia. Children with retinopathy-positive CM (n = 172) had higher total and sequestered parasite burdens compared to retinopathy-negative children (n = 42) (both

Indexed as

malariapediatricsretinopathy

Identifiers

PMID39591285
PMCPMC11598592

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