Evidence map›Paper›PMID 39591258›Full record

ArticleTropical medicine and infectious disease2024

Differences in Cytokine Expression at Baseline and in Response to Mineral Stimulation by Peripheral Blood Mononuclear Cells from Podoconiosis Cases and Healthy Control Individuals.

Mikias Negash, Tigist Girma, Menberework Chanyalew, Dawit H Alemayehu, Diana Alcantara, Gail Davey, Rosemary J Boyton, Daniel M Altmann, Melanie J Newport, Rawleigh Howe

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Article in Tropical medicine and infectious disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mikias NegashBrighton and Sussex Centre for Global Health Research, Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton BN1 9PX, UK.
Tigist GirmaArmauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.
Menberework ChanyalewArmauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.ORCID 0000-0002-4154-2100
Dawit H AlemayehuArmauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.
Diana AlcantaraBrighton and Sussex Centre for Global Health Research, Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton BN1 9PX, UK.
Gail DaveyBrighton and Sussex Centre for Global Health Research, Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton BN1 9PX, UK.ORCID 0000-0003-2796-7468
Rosemary J BoytonDepartment of Infectious Disease, Imperial College London, London W2 1PG, UK.
Daniel M AltmannDepartment of Immunology and Inflammation, Imperial College London, London W12 0NN, UK.ORCID 0000-0002-2436-6192
Melanie J NewportBrighton and Sussex Centre for Global Health Research, Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton BN1 9PX, UK.ORCID 0000-0002-8946-7525
Rawleigh HoweArmauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.

Funding

Medical Research Council MR/W020610/1National Institute for Health Research (NIHR) Official Development Assistance (ODA) [Grant number GHR 16/136/29].
6 · The paper itself

Abstract

Epidemiological, histological, and immunogenetic studies suggest that podoconiosis (a non-infectious tropical lymphoedema affecting approximately 4 million people globally) is an HLA class II-associated inflammatory condition that develops in response to an unknown trigger found in volcanic red clay soils. Silicate particles of the kaolinite and aluminum types have been identified in femoral lymph node biopsy samples from endemic area residents, suggesting a possible role in the pathogenesis of podoconiosis. We measured in vitro peripheral blood mononuclear cell cytokine responses (

Indexed as

gene expressionmineral stimulationnon-filarial lymphoedemapodoconiosispro-inflammatory cytokines

Identifiers

PMID39591258
PMCPMC11598685

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.