Evidence map›Paper›PMID 39591134›Full record

ArticleVaccines2024

Proceedings of the Conference "CMV Vaccine Development-How Close Are We?" (27-28 September 2023).

Mark R Schleiss, Chelsea M Crooks, Krithika P Karthigeyan, Rebecca M Kruc, Claire E Otero, Hsuan-Yuan Sherry Wang, Sallie R Permar, Stanley A Plotkin, Rajeev Gautam

Abstract readConference Proceedings
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Quantitative measures of humanPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  6. Review
  7. Review
  8. An OralPathogens (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Article
  11. Oral Vaccination with AttenuatedPathogens (Basel, Switzerland) · 2025
    Article
  12. A vaccine against cytomegalovirus: how close are we?The Journal of clinical investigation · 2025
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mark R SchleissDivision of Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, 2001 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0002-2108-9433
Chelsea M CrooksBB-869-H, Belfer Research Building, Weill Cornell Medicine, 413 East 69th Street, New York, NY 10021, USA.ORCID 0000-0003-3874-4577
Krithika P KarthigeyanBB-869-H, Belfer Research Building, Weill Cornell Medicine, 413 East 69th Street, New York, NY 10021, USA.
Rebecca M KrucDepartment of Pediatrics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Claire E OteroBB-869-H, Belfer Research Building, Weill Cornell Medicine, 413 East 69th Street, New York, NY 10021, USA.
Hsuan-Yuan Sherry WangBB-869-H, Belfer Research Building, Weill Cornell Medicine, 413 East 69th Street, New York, NY 10021, USA.
Sallie R PermarDepartment of Pediatrics, Weill Cornell Medicine, 1300 York Ave Box 65, New York, NY 10065, USA.ORCID 0000-0003-1438-4554
Stanley A PlotkinPerelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Building 421, Philadelphia, PA 19104, USA.
Rajeev GautamProgram Officer at Virology Branch, Division of Microbiology and Infectious Diseases, NIAID, NIH, 5601 Fisher's Lane, Rockville, MD 20892, USA.ORCID 0000-0003-2390-8727

Funding

Virology CoreP01AI129859 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Sallie R. Permar · 2019 to 2026
$31.0M
Optimizing Immunity and Maternal Host Defense Against Congenital Cytomegalovirus InfectionR01HD098866 · NICHD · UNIVERSITY OF MINNESOTA · PI Craig John Bierle, Michael A McVoy · 2019 to 2026
$3.9M
Identifying and modeling immune correlates of protection against congenital CMV transmission after primary maternal infectionR01AI173333 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Sallie R. Permar · 2023 to 2026
$3.3M
Improving HCMV vaccine-elicited immunity by targeting viral Fc receptorsR21AI176451 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI PERMAR, SALLIE R. · 2024 to 2025
$429k
NIAID NIH HHS P01 AI129859NIAID NIH HHS R01 AI173333NIAID NIH HHS R21 AI176451NICHD NIH HHS L50 HD099866NICHD NIH HHS R01 HD098866NIH HHS NIH R01HD099866 (MRS), R01AI173333 (SAP), P01 P01AI129859 (SAP) and R21 AI176451 (SAP)
6 · The paper itself

Abstract

Congenital cytomegalovirus (cCMV) is the most common infectious cause of disability in children, including sensorineural hearing loss. There is interest in developing a pre-conception vaccine that could confer protective immunity on a woman of child-bearing age, hence resulting in a reduced cCMV disease burden. Other populations, including solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) patients, could also benefit from CMV vaccination. To review and discuss vaccines that are in clinical development, a workshop, sponsored by the National Institutes of Health (NIH) and the National Institute of Allergy and Infectious Diseases (NIAID), was empaneled. At this workshop, correlates of protective immunity against CMV, epidemiologic features of CMV transmission, and vaccine platforms in development were reviewed. Representatives from academia, pharma, and the NIH engaged in discussion on the current state-of-the-art in CMV vaccinology. A summary of the presentations from this is provided in this report.

Indexed as

CMV advocacyCMV immunityCMV vaccinecongenital cytomegalovirus (CMV)

Identifiers

PMID39591134
PMCPMC11598149

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.