Evidence map›Paper›PMID 39591129›Full record

ArticleVaccines2024

Beyond Awareness: Hope for a CMV Vaccine! An Introduction to the Conference, "CMV Vaccine Development-How Close Are We?" (27-28 September 2023).

Megan H Pesch, Mark R Schleiss, Stanley A Plotkin, Sallie R Permar, Rajeev Gautam

Abstract readConference Proceedings
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Megan H PeschDivision of Developmental and Behavioral Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8212-2241
Mark R SchleissDivision of Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, 2001 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0002-2108-9433
Stanley A PlotkinPerelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Building 421, Philadelphia, PA 19104, USA.
Sallie R PermarDepartment of Pediatrics, Weill Cornell Medicine, 1300 York Ave Box 65, New York, NY 10065, USA.ORCID 0000-0003-1438-4554
Rajeev GautamProgram Officer at Virology Branch, Division of Microbiology and Infectious Diseases, NIAID, NIH, 5601 Fisher's Lane, Rockville, MD 20892, USA.ORCID 0000-0003-2390-8727

Funding

Virology CoreP01AI129859 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Cliburn C Chan · 2019 to 2026
$31.0M
Optimizing Immunity and Maternal Host Defense Against Congenital Cytomegalovirus InfectionR01HD098866 · NICHD · UNIVERSITY OF MINNESOTA · PI Craig John Bierle, Michael A McVoy · 2019 to 2026
$3.9M
Identifying and modeling immune correlates of protection against congenital CMV transmission after primary maternal infectionR01AI173333 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Sallie R. Permar · 2023 to 2026
$3.3M
Congenital cytomegalovirus: Infant developmental trajectories and parent experiencesK23HD108278 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PESCH, MEGAN H. · 2022 to 2025
$678k
Improving HCMV vaccine-elicited immunity by targeting viral Fc receptorsR21AI176451 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI PERMAR, SALLIE R. · 2024 to 2025
$429k
NIAID NIH HHS P01 AI129859NIAID NIH HHS R01 AI173333NIAID NIH HHS R21 AI176451NICHD NIH HHS K23 HD108278NICHD NIH HHS L50 HD099866NICHD NIH HHS R01 HD098866NIH HHS 5K23HD108278-02 (MHP), NIH R01HD099866 (MRS), R01AI173333 (SRP), P01 P01AI129859 (SRP) and R21 AI176451 (SRP).
6 · The paper itself

Abstract

Congenital cytomegalovirus (cCMV) is the most common infectious cause of disability in children. The major theme of this National Institute of Allergy and Infectious Diseases (NIAID) workshop, "CMV Vaccine Development-How Close Are We?", was to report progress on the development of a pre-conception vaccine that could confer protective immunity for women of child-bearing age. Such a vaccine could result in a reduced cCMV disease burden, although other populations, including solid organ transplant and hematopoietic stem cell transplant patients, could benefit as well. To frame the compelling need for a cCMV vaccine, a keynote lecture by Dr. Megan Pesch, immediate past-president of the National CMV Foundation and a leading cCMV researcher from the University of Michigan, was given. This manuscript provides a summary of Dr. Pesch's presentation from this workshop, which was written as the introductory conference report for the meeting.

Indexed as

CMV advocacyCMV immunityCMV vaccinecongenital cytomegalovirus (CMV)

Identifiers

PMID39591129
PMCPMC11598857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.