Evidence map›Paper›PMID 39591114›Full record

ArticleVaccines2024

Neutralizing Antibody-Mediated Protection from Prior Delta Variant Infection Against Omicron BA.5 Sub-Lineage Reinfection One Year Later: A Prospective Cohort Study.

Shihan Zhang, Yin Wang, Guo Xu, Chen Dong, Hua Tian, Chuchu Li, Xiaoxiao Kong, Jiefu Peng, Haodi Huang, Aidibai Simayi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shihan ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China.
Yin WangDepartment of Acute Infectious Disease Control and Prevention, Yangzhou Center for Disease Control and Prevention, Yangzhou 225007, China.
Guo XuKey Laboratory of Infectious Diseases, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Chen DongDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Hua TianDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Chuchu LiDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Xiaoxiao KongDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Jiefu PengDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Haodi HuangDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Aidibai SimayiDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China.
Fengcai ZhuNational Health Commission (NHC) Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Jianli HuDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Ke XuDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Changjun BaoDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Hui JinDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China.ORCID 0000-0003-0071-9755
Liguo ZhuDepartment of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.

Funding

Scientific research project of Jiangsu health commission DX202301, Z2020050Social Development Foundation of Jiangsu Province BE2021739
6 · The paper itself

Abstract

backgroundPrevious SARS-CoV-2 infection provides some level of protection against reinfection. However, few studies have evaluated the neutralizing antibody (NAb) response after Delta variant infection and its ability to prevent reinfection with Omicron BA.5 one year later.

methodsThis prospective cohort study included 431 patients who recovered from Delta variant infection. We measured their serum NAb titers against both Delta and Omicron BA.5 using microneutralization tests.

resultsOver a 17-month follow-up, 17.9% of the participants were reinfected with Omicron BA.5. Younger adults (18-65 years) and individuals who did not receive booster immunization had significantly higher reinfection rates than older adults (>65 years) and those who received boosters (

conclusionsDelta-variant infection-induced NAbs did not strongly predict protection against Omicron BA.5 reinfection. However, booster immunization effectively reduced the reinfection rate approximately one year after the initial Delta infection.

Indexed as

Delta variantneutralizing antibodyOmicron BA.5reinfectionSARS-CoV-2

Identifiers

PMID39591114
PMCPMC11598881

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.