Evidence map›Paper›PMID 39590854›Full record

ArticleMetabolites2024

Unraveling the Association of Liver Steatosis and Fibrosis with Vitamin B12: A Cross-Sectional Study.

Silvia Espina, Diego Casas-Deza, Vanesa Bernal-Monterde, Ana Royo-Esteban, Maria Pilar García-Sobreviela, Pilar Calmarza, Ana B Martinez-Martinez, Jesús Osada, Jose M Arbones-Mainar

Abstract read
In one paragraph

Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silvia EspinaGastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain.ORCID 0000-0003-1632-9903
Diego Casas-DezaGastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Vanesa Bernal-MonterdeGastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Ana Royo-EstebanGastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Maria Pilar García-SobrevielaAdipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Pilar CalmarzaClinical Biochemistry Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Ana B Martinez-MartinezAdipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, Miguel Servet University Hospital, 50009 Zaragoza, Spain.ORCID 0000-0002-1557-7545
Jesús OsadaInstituto de Investigacion Sanitaria (IIS) Aragon, 50009 Zaragoza, Spain.ORCID 0000-0002-8251-8457
Jose M Arbones-MainarAdipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, Miguel Servet University Hospital, 50009 Zaragoza, Spain.ORCID 0000-0002-8982-3737

Funding

Gobierno de Aragón B03_23RInstituto de Salud Carlos III PI22/01366Instituto de Salud Carlos III PMP21/00094
6 · The paper itself

Abstract

backgroundThere are conflicting studies reporting both an increase and a decrease in vitamin B12 (VB12) levels in non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to dissect the effects of steatosis and fibrosis on VB12.

methodsThis is a cross-sectional study including all patients with a vibration-controlled transient elastography (VCTE) performed at the Hospital Miguel Servet (Zaragoza, Spain) between 2019 and 2022 for a chronic liver disease and having a recent blood test for VB12 levels. Liver fibrosis was assessed by VCTE and hepatic steatosis by ultrasonography and/or through controlled attenuation parameter (CAP).

results1195 patients (NAFLD

conclusionVB12 levels were lower with greater hepatic steatosis. In NAFLD, VB12 levels were lower compared to other chronic liver diseases but their levels increased with higher liver stiffness and in cirrhosis stage.

Indexed as

cirrhosisfatty liverNAFLDtransient elastography

Identifiers

PMID39590854
PMCPMC11597091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.