ArticleBiomimetics (Basel, Switzerland)2024
Sodium Alginate-Starch Capsules for Enhanced Stability of Metformin in Simulated Gastrointestinal Fluids.
Article in Biomimetics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Enhanced Storage Stability and Gastrointestinal Survival of Lactiplantibacillus plantarum by Sodium Alginate-Resistant Starch-EGCG Composite Encapsulation.Journal of food science · 2026Article
- Physicochemical and Functional Properties of Polyphenolic Core Gel Microcapsules from Rose Petals (Foods (Basel, Switzerland) · 2026Article
- Biopolymer-Based Gel Capsules for Improved Probiotic Delivery.Gels (Basel, Switzerland) · 2026Article
- Survival ofFoods (Basel, Switzerland) · 2025Article
- Programmatically activated DNA hydrogel microcapsules for precision therapy in inflammatory bowel disease.Theranostics · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of biopolymers in pharmaceuticals is well established, particularly for encapsulating biologically active compounds due to their beneficial properties. Alginate, widely recognized for its excellent encapsulation abilities, is the most commonly used biopolymer, while starch, typically known as insoluble dietary fiber, also serves as an effective agent for trapping and protecting compounds during processing, storage, and gastrointestinal transit. Sodium alginate-starch capsules with varying compositions were analyzed to develop metformin hydrochloride (MET) containing capsules with adequate physicochemical properties. In vitro testing with simulated gastrointestinal fluids showed that after 1 h, capsules with equal amounts of alginate and starch had a higher swelling ratio and better drug release behavior, despite lower MET entrapment efficiency compared to other formulations. Microstructural analysis revealed stability in simulated gastric fluids and solubility in simulated intestinal fluids, key factors in drug development. The results suggest that these biopolymeric compositions are highly resistant to gastric fluids and minimally soluble in the intestines, making them suitable for extended drug release. This research evaluates key technological parameters of a cost-effective encapsulation method for the controlled release of active substances, providing a versatile solution for pharmaceutical and biomedical applications.
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Registered trials
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