Evidence map›Paper›PMID 39590276›Full record

ArticleBiomimetics (Basel, Switzerland)2024

Evaluation of the In Vitro Behavior of Electrochemically Deposited Plate-like Crystal Hydroxyapatite Coatings.

Cosmin M Cotrut, Alexandru Blidisel, Diana M Vranceanu, Alina Vladescu Dragomir, Elena Ungureanu, Iulian Pana, Mihaela Dinu, Catalin Vitelaru, Anca C Parau, Vasile Pruna and 2 more

Abstract read
In one paragraph

Article in Biomimetics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cosmin M CotrutFaculty of Materials Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Independentei Street, 060042 Bucharest, Romania.ORCID 0000-0002-8991-7485
Alexandru BlidiselHepato-Bilio-Pancreatic Surgery Center, University Clinic Surgical Semiology and Thoracic Surgery, "Victor Babes" University of Medicine and Pharmacy, Sq. Eftimie Murgu No. 2, 300041 Timisoara, Romania.ORCID 0000-0001-6528-7733
Diana M VranceanuFaculty of Materials Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Independentei Street, 060042 Bucharest, Romania.ORCID 0000-0002-6561-7023
Alina Vladescu DragomirDepartment for Advanced Surface Processing and Analysis by Vacuum Technologies, National Institute of Research and Development for Optoelectronics-INOE 2000, 077125 Magurele, Romania.ORCID 0000-0001-5770-4541
Elena UngureanuFaculty of Materials Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Independentei Street, 060042 Bucharest, Romania.
Iulian PanaDepartment for Advanced Surface Processing and Analysis by Vacuum Technologies, National Institute of Research and Development for Optoelectronics-INOE 2000, 077125 Magurele, Romania.ORCID 0000-0003-1368-6219
Mihaela DinuDepartment for Advanced Surface Processing and Analysis by Vacuum Technologies, National Institute of Research and Development for Optoelectronics-INOE 2000, 077125 Magurele, Romania.ORCID 0000-0002-3149-6972
Catalin VitelaruDepartment for Advanced Surface Processing and Analysis by Vacuum Technologies, National Institute of Research and Development for Optoelectronics-INOE 2000, 077125 Magurele, Romania.ORCID 0000-0002-8686-8577
Anca C ParauDepartment for Advanced Surface Processing and Analysis by Vacuum Technologies, National Institute of Research and Development for Optoelectronics-INOE 2000, 077125 Magurele, Romania.ORCID 0000-0002-4661-8362
Vasile PrunaRomanian Academy Institute of Cellular Biology and Pathology "Nicolae Simionescu", 8 B.P. Hasdeu, 050568 Bucharest, Romania.
Mihai S MagureanColentina Clinical Hospital, 020125 Bucharest, Romania.
Irina TitorencuRomanian Academy Institute of Cellular Biology and Pathology "Nicolae Simionescu", 8 B.P. Hasdeu, 050568 Bucharest, Romania.

Funding

Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii PN-III-P2-2.1-PED-2021-4275 (621PED/2022; BioMimCells)
6 · The paper itself

Abstract

The purpose of coatings is to protect or enhance the functionality of the substrate material, irrespective of the field in which the material was designed. The use of coatings in medicine is rapidly expanding with the objective of enhancing the osseointegration ability of metallic materials such as titanium. The aim of this study was to obtain biomimetic hydroxyapatite (HAp)-based coatings on titanium by using the pulsed galvanostatic method. The morphology of the HAp-based coatings revealed the presence of very thin and wide plate-like crystals, grown perpendicular to the Ti substrate, while the chemical composition highlighted a Ca/P ratio of 1.66, which is close to that of stoichiometric HAp (1.67). The main phases and chemical bonds identified confirmed the presence of the HAp phase in the developed coatings. A roughness of 228 nm and a contact angle of approx. 17° were obtained for the HAp coatings, highlighting a hydrophilic character. In terms of biomineralization and electrochemical behavior, it was shown that the HAp coatings have significantly enhanced the titanium properties. Finally, the in vitro cell tests carried out with human mesenchymal stem cells showed that the Ti samples coated with HAp have increased cell viability, extracellular matrix, and Ca intracellular deposition when compared with the uncoated Ti, indicating the beneficial effect.

Indexed as

biocompatibilitybiomimeticelectrochemical depositionhydroxyapatite coatingssurface modification

Identifiers

PMID39590276
PMCPMC11592108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.