Evidence map›Paper›PMID 39590262›Full record

ReviewBiomimetics (Basel, Switzerland)2024

Advances in Bioceramics for Bone Regeneration: A Narrative Review.

Baylee M Brochu, Savanah R Sturm, Joao Arthur Kawase De Queiroz Goncalves, Nicholas A Mirsky, Adriana I Sandino, Kayaan Zubin Panthaki, Karl Zubin Panthaki, Vasudev Vivekanand Nayak, Sylvia Daunert, Lukasz Witek and 1 more

Abstract readReview
In one paragraph

Review in Biomimetics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Applications of DNA Hydrogels in Osteoporotic Bone Defects.Journal of functional biomaterials · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Observational
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Baylee M BrochuUniversity of Miami Miller School of Medicine, Miami, FL 33136, USA.
Savanah R SturmUniversity of Miami Miller School of Medicine, Miami, FL 33136, USA.
Joao Arthur Kawase De Queiroz GoncalvesUniversity of Miami Miller School of Medicine, Miami, FL 33136, USA.
Nicholas A MirskyUniversity of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0009-0005-0941-6605
Adriana I SandinoUniversity of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0009-0007-7012-0920
Kayaan Zubin PanthakiDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0009-0003-6989-5164
Karl Zubin PanthakiDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0009-0009-7014-0977
Vasudev Vivekanand NayakDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0003-2739-0339
Sylvia DaunertDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Lukasz WitekBiomaterials Division, NYU Dentistry, 345 E. 24th St., Room 806, New York, NY 10010, USA.ORCID 0000-0003-1458-6527
Paulo G CoelhoDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Funding

Purinergic Stimulation of Bone RegenerationR01AR068593 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COELHO, PAULO G, CRONSTEIN, BRUCE NEIL · 2015 to 2019
$2.8M
Engineering Personalized Devices for Craniomaxillofacial DefectsR33HD090664 · NICHD · NEW YORK UNIVERSITY · PI CRONSTEIN, BRUCE NEIL, FLORES, ROBERTO L · 2019 to 2021
$1.2M
Engineering Personalized Devices for Craniomaxillofacial DefectsR21HD090664 · NICHD · NEW YORK UNIVERSITY · PI COELHO, PAULO G, CRONSTEIN, BRUCE NEIL · 2017 to 2018
$452k
NIH-NIAMS R01AR068593NIH-NICHD R21HD090664NIH-NICHD R33HD090664US Department of Defense W81XWH-16-1-0772
6 · The paper itself

Abstract

Large osseous defects resulting from trauma, tumor resection, or fracture render the inherent ability of the body to repair inadequate and necessitate the use of bone grafts to facilitate the recovery of both form and function of the bony defect sites. In the United States alone, a large number of bone graft procedures are performed yearly, making it an essential area of investigation and research. Synthetic grafts represent a potential alterative to autografts due to their patient-specific customizability, but currently lack widespread acceptance in the clinical space. Early in their development, non-autologous bone grafts composed of metals such as stainless steel and titanium alloys were favorable due to their biocompatibility, resistance to corrosion, mechanical strength, and durability. However, since their inception, bioceramics have also evolved as viable alternatives. This review aims to present an overview of the fundamental prerequisites for tissue engineering devices using bioceramics as well as to provide a comprehensive account of their historical usage and significant advancements over time. This review includes a summary of commonly used manufacturing techniques and an evaluation of their use as drug carriers and bioactive coatings-for therapeutic ion/drug release, and potential avenues to further enhance hard tissue regeneration.

Indexed as

bioceramicsbone graftsbone tissue regeneration

Identifiers

PMID39590262
PMCPMC11592113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.