ArticleBiomimetics (Basel, Switzerland)2024
ROS Scavenging and Osteogenic Differentiation Potential of L-Methionine-Substituted Poly(Organophosphazene) Electrospun Fibers.
Article in Biomimetics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigated the application of poly[bis (ethylmethionato) phosphazene] (PαAPz-M) electrospun fibers in tissue engineering, focusing on their reactive oxygen species (ROS) scavenging capabilities and material-directed cell behavior, including the influence of their degradation products on cell viability and differentiation, and the scaffold topography's influence on cell alignment. The ROS scavenging ability of PαAPz-M was assessed by DPPH assay, and then PαAPz-M's protection against exogenous ROS was studied. The results showed enhanced cell viability on PαAPz-M fiber mats under oxidative stress conditions. This study also investigated the effects of the degradation products of PαAPz-M on cell viability and osteogenic differentiation. It was observed that the late-stage degradation product, phosphoric acid, can significantly influence the osteogenic differentiation of MSCs. In contrast, methionine, which is the early-stage degradation product, showed a minimal influence. Additionally, the study fabricated fiber mats that can lead to enhanced cell alignment while maintaining high porosity. Collectively, this study expanded the applications of PαAPz-M fiber mat protection against oxidative stress and guiding osteogenic differentiation and cell alignment.
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