Evidence map›Paper›PMID 39590247›Full record

ReviewBiomimetics (Basel, Switzerland)2024

Mechanical Properties of Cocoon Silk Derivatives for Biomedical Application: A Systematic Review.

Alynah J Adams, Maria J Escobar-Domingo, Jose Foppiani, Agustin N Posso, Dorien I Schonebaum, Noelle Garbaccio, Jade E Smith, Lacey Foster, Audrey K Mustoe, Micaela Tobin and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomimetics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alynah J AdamsSchool of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-3434-0287
Maria J Escobar-DomingoDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-4677-471X
Jose FoppianiDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0003-2783-3531
Agustin N PossoDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0009-0009-8206-0448
Dorien I SchonebaumLeiden University Medical Centre, Leiden University, 2311 EZ Leiden, The Netherlands.
Noelle GarbaccioChobanian & Avedisian School of Medicine, Boston University, Boston, MA 02214, USA.
Jade E SmithNorthwestern Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-7373-3817
Lacey FosterKeck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Audrey K MustoeDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Micaela TobinDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Bernard T LeeDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-5533-3166
Samuel J LinDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite cocoon silk's well-known strength, biocompatibility, and hypoallergenic properties, its potential medical applications remain largely unexplored. This review, therefore, is of significance as it evaluates the mechanical properties and clinical potential of cocoon silk, a material with promising applications in biomaterials and tissue engineering.

methodsWe conducted a comprehensive systematic review adhering to PRISMA guidelines. Our focus was on the primary outcomes of tensile strength and elongation at break, and the secondary outcomes included other mechanical properties, applications, and complications.

resultsOut of the 192 silk-related studies, 9 met the criteria. These studies revealed that cocoon silk derivatives exhibit a wide range of tensile strength, from 0.464 to 483.9 MPa (with a median of 4.27 MPa), and elongation at break, from 2.56% to 946.5% (with a median of 60.0%). Biomedical applications of cocoon silk derivatives span from tissue regeneration (

conclusionsWhile cocoon silk shows expansive promise due to its suitable mechanical properties and low complication risk, plenty remains to be discovered. Future research is crucial to fully realizing its vast surgical and biomedical potential.

Indexed as

biomedicinecocoon silkmechanical propertiessilksystematic review

Identifiers

PMID39590247
PMCPMC11592187

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.