Evidence map›Paper›PMID 39590211›Full record

ArticleJournal of cardiovascular development and disease2024

Beyond the Obesity Paradox: Analysis of New Prognostic Factors in Transcatheter Aortic Valve Implantation Procedure.

Francesca Ricci, Leonardo Benelli, Monia Pasqualetto, Mario Laudazi, Luca Pugliese, Maria Volpe, Cecilia Cerimele, Carlo Di Donna, Francesco Garaci, Marcello Chiocchi

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesca RicciDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.ORCID 0000-0001-5566-9519
Leonardo BenelliDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.ORCID 0000-0002-2807-5747
Monia PasqualettoDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.
Mario LaudaziDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.ORCID 0000-0001-6094-6330
Luca PuglieseDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.ORCID 0000-0001-9061-7247
Maria VolpeDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.
Cecilia CerimeleDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.ORCID 0000-0002-5137-9124
Carlo Di DonnaDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.ORCID 0000-0001-9241-1859
Francesco GaraciDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.
Marcello ChiocchiDepartment of Biomedicine and Prevention Division of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.ORCID 0000-0001-6041-4166

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeThe main purpose of our study was to collect computed tomography (CT) measurements of fat parameters that are significantly related to body mass index (BMI) and evaluate the associations of these measurements and sarcopenia with early and long-term complications after transcatheter aortic valve implantation (TAVI) in order to investigate the existence of the so-called 'obesity paradox' and the role of sarcopenia in this phenomenon. MATERIALS AND

methodsWe analyzed the significance of fat CT measurements in 85 patients undergoing the TAVI procedure and compared these with each other, as well as with quantified CT BMI and fat density measurements. Secondly, we evaluated the associations of BMI, CT measurements of fat, and CT evaluations of skeletal muscle mass with early and long-term complications after 24 months of post-TAVI follow-up.

resultsWe found positive and significant relationships between fat CT measurements with each other and with BMI and a negative and significant relation between fat density and fat quantity. By comparing the CT measurements of fat and skeletal muscle mass with early and long-term complications after TAVI, we confirmed the existence of the 'obesity paradox' and the poor effect of sarcopenia after the TAVI procedure.

conclusionsWe confirm that overweight and obesity are good prognostic factors, and sarcopenia is a poor prognostic factor for outcomes following the TAVI procedure. We focused on the scientific validation of an easy and fast way to measure fat and skeletal muscle mass using CT to better predict the outcomes of patients undergoing TAVI.

Indexed as

BMICTfat densityobesity paradoxsarcopeniaTAVI

Identifiers

PMID39590211
PMCPMC11594374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.