Evidence map›Paper›PMID 39590195›Full record

ArticleJournal of cardiovascular development and disease2024

An In Vivo Model of Estrogen Supplementation Concerning the Expression of Ca

Tomáš Toporcer, Tomáš Grendel, Ivana Špaková, Alžbeta Blichárová, Ľudmila Verbóová, Zuzana Benetinová, Beata Čižmárová, Miroslava Rabajdová, Silvia Toporcerová

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In one paragraph

Article in Journal of cardiovascular development and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tomáš ToporcerDepartment of Heart Surgery, East Slovak Institute of Cardiovascular Disease and Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia.ORCID 0000-0003-4195-5180
Tomáš GrendelDepartment of Anesthesiology and Intensive Medicine, East Slovak Institute of Cardiovascular Disease and Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia.
Ivana ŠpakováDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia.
Alžbeta BlichárováDepartment of Pathology, Louis Pasteur University Hospital and Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.ORCID 0000-0001-5719-5484
Ľudmila VerbóováDepartment of Pathology, Louis Pasteur University Hospital and Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.ORCID 0000-0003-2507-6258
Zuzana BenetinováDepartment of Pathology, Louis Pasteur University Hospital and Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.ORCID 0000-0001-6990-8760
Beata ČižmárováDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia.ORCID 0000-0001-8699-3581
Miroslava RabajdováDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia.
Silvia ToporcerováDepartment of Gynecology and Obstetrics, Faculty of Medicine, Pavol Jozef Šafárik University and Gyncare, 040 11 Košice, Slovakia.

Funding

The Ministry of Education, Research, Development and Youth of the Slovak Republic 012UPJŠ-4/2023
6 · The paper itself

Abstract

backgroundIschemic-reperfusion damage of cardiomyocytes due to myocardial infarction (MI) often leads to the death of an individual. Premenopausal women have been observed to have a significantly lower risk of cardiovascular disease (CVD) than men of the same age. In menopausal women, this trend is significantly reversed, and the risk of CVD increases up to 10-fold. Estrogens affect the development and function of the heart muscle, and as they decrease, the risk and poor prognosis of CVD increase. This study is focused on the effects of estrogen supplementation on morbidity, vitality, and

methodsIn this study, female Sprague Dawley rats (n = 58), which were divided into three experimental groups (NN-control group, non-supplemented; OVX-N-ovariectomized, non-supplemented; OVX-S-ovariectomized, supplemented), received left thoracotomy in the fourth intercostal space. The left anterior descendent coronary artery was ligated 2 mm from its origin with an 8.0 suture. An immunohistological analysis as well as an RT-PCR analysis of

resultsA higher survival rate was recorded in the OVX-N group (86%) in comparison with the OVX-S group (53%) (

conclusionsThis study provides a comprehensive description of the effect of estrogen supplementation on

Indexed as

estrogen supplementationmyocardial infarctionNCX1ovariectomized ratrhythm disorders

Identifiers

PMID39590195
PMCPMC11595027

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