Evidence map›Paper›PMID 39590151›Full record

ArticleCurrent oncology (Toronto, Ont.)2024

Modification and Validation of the System Causability Scale Using AI-Based Therapeutic Recommendations for Urological Cancer Patients: A Basis for the Development of a Prospective Comparative Study.

Emily Rinderknecht, Dominik von Winning, Anton Kravchuk, Christof Schäfer, Marco J Schnabel, Stephan Siepmann, Roman Mayr, Jochen Grassinger, Christopher Goßler, Fabian Pohl and 9 more

Abstract readComparative StudyValidation Study
In one paragraph

Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Emily RinderknechtDepartment of Urology, Caritas St. Josef Hospital, University of Regensburg,93053 Regensburg, Germany.
Dominik von WinningDepartment of Urology, St. Elisabeth Hospital Straubing, 94315 Straubing, Germany.
Anton KravchukDepartment of Urology, St. Elisabeth Hospital Straubing, 94315 Straubing, Germany.ORCID 0009-0003-3365-1563
Christof SchäferDepartment of Radiotherapy, Straubing Hospital Medical Care Centre, 94315 Straubing, Germany.
Marco J SchnabelDepartment of Urology, Caritas St. Josef Hospital, University of Regensburg,93053 Regensburg, Germany.ORCID 0000-0002-1535-2952
Stephan SiepmannDepartment of Urology, St. Elisabeth Hospital Straubing, 94315 Straubing, Germany.
Roman MayrDepartment of Urology, Caritas St. Josef Hospital, University of Regensburg,93053 Regensburg, Germany.ORCID 0000-0003-1796-3260
Jochen GrassingerDepartment of Hematology and Oncology, Straubing Hospital Medical Care Centre, 94315 Straubing, Germany.
Christopher GoßlerDepartment of Urology, Caritas St. Josef Hospital, University of Regensburg,93053 Regensburg, Germany.ORCID 0000-0002-6376-7669
Fabian PohlDepartment of Radiotherapy, University Hospital Regensburg, 93053 Regensburg, Germany.
Peter J SiskaDepartment of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-1521-6213
Florian ZemanCenter for Clinical Studies, University Hospital Regensburg, 93053 Regensburg, Germany.
Johannes BreyerDepartment of Urology, Caritas St. Josef Hospital, University of Regensburg,93053 Regensburg, Germany.
Anna SchmelzerDepartment of Urology, St. Elisabeth Hospital Straubing, 94315 Straubing, Germany.
Christian GilfrichDepartment of Urology, St. Elisabeth Hospital Straubing, 94315 Straubing, Germany.ORCID 0000-0003-0211-0636
Sabine D Brookman-MayDepartment of Urology, Ludwig-Maximilians-University (LMU), 80539 Munich, Germany.
Maximilian BurgerDepartment of Urology, Caritas St. Josef Hospital, University of Regensburg,93053 Regensburg, Germany.
Maximilian HaasDepartment of Urology, Caritas St. Josef Hospital, University of Regensburg,93053 Regensburg, Germany.ORCID 0000-0003-3132-0130
Matthias MayDepartment of Urology, St. Elisabeth Hospital Straubing, 94315 Straubing, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of artificial intelligence, particularly Large Language Models (LLMs), has the potential to significantly enhance therapeutic decision-making in clinical oncology. Initial studies across various disciplines have demonstrated that LLM-based treatment recommendations can rival those of multidisciplinary tumor boards (MTBs); however, such data are currently lacking for urological cancers. This preparatory study establishes a robust methodological foundation for the forthcoming CONCORDIA trial, including the validation of the System Causability Scale (SCS) and its modified version (mSCS), as well as the selection of LLMs for urological cancer treatment recommendations based on recommendations from ChatGPT-4 and an MTB for 40 urological cancer scenarios. Both scales demonstrated strong validity, reliability (all aggregated Cohen's K > 0.74), and internal consistency (all Cronbach's Alpha > 0.9), with the mSCS showing superior reliability, internal consistency, and clinical applicability (

Indexed as

Artificial IntelligenceUrologic NeoplasmsHumansProspective StudiesReproducibility of Resultsartificial intelligence integrationartificial neural networkclinical decision supportlarge language modelsmultidisciplinary tumor boardsnon-inferiority CONCORDIA TrialSCSurological cancer treatmentvalidation study

Identifiers

PMID39590151
PMCPMC11593082

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.