Evidence map›Paper›PMID 39590121›Full record

ReviewCurrent oncology (Toronto, Ont.)2024

Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies.

Pasquale Niscola, Valentina Gianfelici, Gianfranco Catalano, Marco Giovannini, Carla Mazzone, Nelida Ines Noguera, Paolo de Fabritiis

Erratum issuedAbstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
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  6. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Pasquale NiscolaHematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, Italy.
Valentina GianfeliciHematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, Italy.
Gianfranco CatalanoDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-6763-2876
Marco GiovanniniHematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, Italy.
Carla MazzoneHematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, Italy.
Nelida Ines NogueraDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-7682-862X
Paolo de FabritiisHematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a heterogeneous blood-related neoplasm that predominantly afflicts older adults with a poor prognosis due to their physical condition and the presence of medical accompanying comorbidities, adverse biological disease features, and suitability for induction intensive chemotherapy and allogenic stem cells transplantation. Recent research into the molecular and biological factors contributing to disease development and progression has led to significant advancements in treatment approaches for older patients with AML. This review article discusses the latest biological and therapeutic developments that are transforming the management of AML in older adults.

Indexed as

Leukemia, Myeloid, AcuteAgedAged, 80 and overHumansMolecular Targeted Therapygenomic profilinghypomethylating agentsintensive chemotherapyquality of lifesupportive caretargeted therapiestransplantation clinical trialsvenetoclax-based combinations

Identifiers

PMID39590121
PMCPMC11592437

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.