ArticleGels (Basel, Switzerland)2024
Kinetic and Mechanistic Release Studies on Hyaluronan Hydrogels for Their Potential Use as a pH-Responsive Drug Delivery Device.
Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Mechanistic Insights into Moxifloxacin HCl Permeability from Nitrocellulose-Based In Situ Gels via Confocal Imaging and DFT Modeling.AAPS PharmSciTech · 2026Article
- Engineering Hydrogels for Intrauterine Adhesion Therapy and Endometrial Regeneration.Gels (Basel, Switzerland) · 2026Review
- Hydrogels for Local Drug Delivery in Biofilm-Associated Periprosthetic Joint Infection: Current Progress and Future Directions.Microorganisms · 2026Review
- Formulation and Release Kinetics of Neomycin Sulfate from a Polymeric Oil-in-Water Emulgel for Topical Application: A Proof-of-Concept Study.Gels (Basel, Switzerland) · 2026Article
- Tunable PVA-Alginate/FeACS omega · 2026Article
- pH-Responsive Inulin-Sodium Alginate Hydrogel Beads for Sustained Oral Delivery of Bacterial Serine Protease.Bioengineering (Basel, Switzerland) · 2026Article
- Freeze-Thaw-Induced Physically Cross-Linked Poly(Vinyl Alcohol)/Alginate Hydrogels Incorporating Silver-Doped Zinc Oxide and Clove Oil.Biopolymers · 2026Article
- Freeze-Thaw-Synthesized PVA/Chitosan Hydrogels: Structure-Property Relationships and ANN Modeling of Swelling and Degradation Behaviors.ACS omega · 2026Article
- Article
- Autonomous Hydrogel Actuators Programmed by Endogenous Biochemical Logic for Dual-Stage Morphing and Drug Release.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Microneedle Technologies for Drug Delivery: Innovations, Applications, and Commercial Challenges.Micromachines · 2026Review
- A Comprehensive Review on Non-natural Amino Acid-based Modifications in Antibacterial Peptides.Mini reviews in medicinal chemistry · 2026Review
- Assessment of Hydrogels for Intra-Articulate Application, Based on Sodium Hyaluronate Doped with Synthetic Polymers and Incorporated with Diclofenac Sodium.International journal of molecular sciences · 2025Article
- Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin.Gels (Basel, Switzerland) · 2025Article
- Plant Exosome-Loaded Intelligent Hydrogels for Osteoporotic Bone Regeneration: Mechanisms and Applications.International journal of nanomedicine · 2025Review
- Research Progress of Drug Delivery Systems Consisting of Hydrogels Loaded with Extracellular Vesicles in Tumor Therapy.Oncology research · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid, a biocompatible polymer, holds significant potential for drug delivery applications. Its variable degree of protonation, which entails tunable physical properties, makes it an ideal candidate for developing pH-sensitive hydrogels. Like other smart drug delivery systems, pH-responsive hydrogels can enhance medical treatment and expedite the healing process. However, the inherent complexity of hydrogels poses challenges in identifying suitable matrix systems. This study evaluates the potential of thiolated hyaluronic acid hydrogels, physically cross-linked with deacetylated disaccharide units of the polymer, for use in drug delivery. Using low-molecular-weight dextrans as model drugs, we investigated the system's response to different pH environments in terms of swelling as well as the kinetic and mechanistic release of the encapsulated compound. The data suggest tunable release properties of the gel regarding drug size and pH value. Our results demonstrate the gel system's potential for smart drug delivery. We anticipate that this system is a promising candidate for use in transdermal wound healing applications and strongly encourage further investigations using other sorts of (model) drugs to gain a more detailed insight into its pH-responsive transport qualities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.