Evidence map›Paper›PMID 39589888›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Flexible bioelectronic systems with large-scale temperature sensor arrays for monitoring and treatments of localized wound inflammation.

Junhan Liu, Zhongzheng Li, Mubai Sun, Lianjie Zhou, Xiaojun Wu, Yifei Lu, Yuting Shao, Chang Liu, Ningge Huang, Bofan Hu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Curvy Surface Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Smart Hydrogels in Wearable Electronics for Wound Treatments.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Junhan LiuDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.ORCID 0009-0007-3022-2738
Zhongzheng LiDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Mubai SunDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Lianjie ZhouDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Xiaojun WuDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Yifei LuDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Yuting ShaoDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Chang LiuDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Ningge HuangDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Bofan HuDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Zhongyuan WuDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Chunyu YouDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Lizhu LiSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Ming WangState Key Laboratory of Integrated Chips and Systems, Fudan University, Shanghai 200438, China.
Ling TaoDepartment of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai 200030, China.
Zengfeng DiState Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Xing ShengDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-8744-1700
Yongfeng MeiDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.
Enming SongDepartment of Materials Science and Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200438, China.ORCID 0000-0002-2658-904X

Funding

Lingang Laboratory LG-QS-202202-02Science and Technology Commission of Shanghai Municipality (STCSM) 22ZR1406400STI 2030-Major Project 2022ZD0209900the National Natural Science Foundation of China 62204057 62304044 12022209
6 · The paper itself

Abstract

Continuous monitoring and closed-loop therapy of soft wound tissues is of particular interest in biomedical research and clinical practices. An important focus is on the development of implantable bioelectronics that can measure time-dependent temperature distribution related to localized inflammation over large areas of wound and offer in situ treatment. Existing approaches such as thermometers/thermocouples provide limited spatial resolution, inapplicable to a wearable/implantable format. Here, we report a conformal, scalable device package that integrates a flexible amorphous silicon-based temperature sensor array and drug-loaded hydrogel for the healing process. This system can enable the spatial temperature mapping at submillimeter resolution and high sensitivity of 0.1 °C, for dynamically localizing the inflammation regions associated with temperature change, automatically followed with heat-triggered drug delivery from hydrogel triggered by wearable infrared light-emitting-diodes. We establish the operational principles experimentally and computationally and evaluate system functionalities with a wide range of targets including live animal models and human subjects. As an example of medical utility, this system can yield closed-loop monitoring/treatments by tracking of temperature distribution over wound areas of live rats, in designs that can be integrated with automated wireless control. These findings create broad utilities of these platforms for clinical diagnosis and advanced therapy for wound healthcare.

Indexed as

InflammationWound HealingAnimalsBiosensing TechniquesHumansHydrogelsMonitoring, PhysiologicRatsTemperatureWearable Electronic DevicesHydrogelsclosed-loop managementin situ therapyremote caretemperature spatial mappingwound inflammation

Identifiers

PMID39589888
PMCPMC11626133

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.