Evidence map›Paper›PMID 39589865›Full record

ArticleBioinformatics (Oxford, England)2024

STRprofiler: efficient comparisons of short tandem repeat profiles for biomedical model authentication.

Jared M Andrews, Michael W Lloyd, Steven B Neuhauser, Margaret Bundy, Emily L Jocoy, Susan D Airhart, Carol J Bult, Yvonne A Evrard, Jeffrey H Chuang, Suzanne Baker

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jared M AndrewsDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, United States.ORCID 0000-0002-0780-6248
Michael W LloydThe Jackson Laboratory, Bar Harbor, ME 04609, United States.
Steven B NeuhauserThe Jackson Laboratory, Bar Harbor, ME 04609, United States.
Margaret BundyThe Jackson Laboratory, Sacramento, CA 95838, United States.
Emily L JocoyThe Jackson Laboratory, Sacramento, CA 95838, United States.
Susan D AirhartThe Jackson Laboratory, Bar Harbor, ME 04609, United States.
Carol J BultThe Jackson Laboratory, Bar Harbor, ME 04609, United States.ORCID 0000-0001-9433-210X
Yvonne A EvrardLeidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, United States.
Jeffrey H ChuangThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, United States.
Suzanne BakerDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, United States.

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
The DNA Damage Response and Tumorigenesis in the BrainP01CA096832 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BAKER, SUZANNE J. · 2003 to 2025
$38.0M
PDXNet Data Commons and Coordinating CenterU24CA224067 · NCI · JACKSON LABORATORY · PI Jeffrey Hsu-Min Chuang · 2017 to 2026
$9.8M
NCI NIH HHS P01 CA096832NCI NIH HHS P01CA096832NCI NIH HHS P30 CA034196NCI NIH HHS U24 CA224067
6 · The paper itself

Abstract

summaryShort tandem repeat (STR) profiling is commonly performed for authentication of biomedical models of human origin, yet no tools exist to easily compare sets of STR profiles to each other or an existing database in a high-throughput manner. Here, we present STRprofiler, a Python package, command line tool, and Shiny application providing methods for STR profile comparison and cross-contamination detection. STRprofiler can be run with custom databases or used to query against the Cellosaurus cell line database. AVAILABILITY AND IMPLEMENTATION: STRprofiler is freely available as a Python package with a rich CLI from PyPI https://pypi.org/project/strprofiler/ with source code available under the MIT license on GitHub https://github.com/j-andrews7/strprofiler and at https://zenodo.org/records/10989034. A web server hosting an example STRprofiler Shiny application backed by a database with data from the National Cancer Institute-funded PDXNet consortium and The Jackson Laboratory PDX program is available at https://sj-bakerlab.shinyapps.io/strprofiler/. Full documentation is available at https://strprofiler.readthedocs.io/en/latest/.

Indexed as

Microsatellite RepeatsSoftwareCell Line AuthenticationDatabases, GeneticHumans

Identifiers

PMID39589865
PMCPMC11634538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.