Evidence map›Paper›PMID 39589689›Full record

ArticleProbiotics and antimicrobial proteins2025

Postbiotic Effect of Escherichia coli CEC15 and Escherichia coli Nissle 1917 on a Murine Model of 5-FU-induced Intestinal Mucositis.

Rafael de Assis Glória, Tales Fernando da Silva, Tomás Andrade Magalhães Gomes, Kátia Duarte Vital, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Ênio Ferreira, Jean-Mark Chatel, Philippe Langella, Claire Cherbuy and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rafael de Assis Glória *Institute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Tales Fernando da Silva *Institute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Tomás Andrade Magalhães GomesInstitute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Kátia Duarte VitalDepartment of clinical and toxicological analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Simone Odília Antunes FernandesDepartment of clinical and toxicological analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Valbert Nascimento CardosoDepartment of clinical and toxicological analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Ênio FerreiraDepartment of General Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Jean-Mark ChatelUniversité Paris Saclay, INRAE, AgroParisTech, UMR1319, MICALIS, Paris, France.
Philippe LangellaUniversité Paris Saclay, INRAE, AgroParisTech, UMR1319, MICALIS, Paris, France.
Claire CherbuyUniversité Paris Saclay, INRAE, AgroParisTech, UMR1319, MICALIS, Paris, France.
Yves Le LoirINRAE, Institut Agro, STLO, 35042, Rennes, France.
Gwénaël JanINRAE, Institut Agro, STLO, 35042, Rennes, France.
Éric GuédonINRAE, Institut Agro, STLO, 35042, Rennes, France.
Vasco Ariston de Carvalho AzevedoInstitute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil. vasco@icb.ufmg.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics are live microorganisms that, when administered in adequate amounts, can bring health benefits to the host. Most of these organisms are found naturally in the human gastrointestinal tract. Escherichia coli strains Nissle 1917 (EcN), and CEC15 have shown beneficial effects in murine models of intestinal inflammation, such as colitis and mucositis. The present study evaluated the effects as postbiotic of heat-inactivated and cell-free supernatant preparations of EcN and CEC15 in attenuating 5-fluorouracil (5-FU)-induced intestinal mucositis in mice and compared them with the probiotic effects of the live preparations. BALB/c mice were fed, by daily gavage, with 10

Indexed as

Escherichia coliFluorouracilMucositisProbioticsAnimalsDisease Models, AnimalHumansIntestinal MucosaMaleMiceMice, Inbred BALB CMucin-2FluorouracilMucin-2Escherichia coli CEC15Escherichia coli Nissle 1917MucositisParaprobioticsPostbioticsProbiotics

Identifiers

PMID39589689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.