Evidence map›Paper›PMID 39589684›Full record

ArticleEndocrine2025

Survival trends and conditional survival in patients with pulmonary metastases from differentiated thyroid carcinoma.

Xiaoyu Ji, Wei Sun, Chengzhou Lv, Jiapeng Huang, Ruonan Yu, Wenwu Dong, Hao Zhang

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Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xiaoyu JiDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.
Wei SunDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.
Chengzhou LvDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.
Jiapeng HuangDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.
Ruonan YuDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.
Wenwu DongDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.
Hao ZhangDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China. haozhang@cmu.edu.cn.

Funding

Applied Basic Research Program of Liaoning Province 2022020225-JH2/1013Science and Technology Project of Shenyang City 21-173-9-31
6 · The paper itself

Abstract

introductionPatients with pulmonary metastases from differentiated thyroid carcinoma (DTC) have a significantly poorer prognosis compared to DTC patients without metastases. This study aimed to establish a nomogram combined with dynamic survival analysis to predict the survival probability of patients with pulmonary metastases from differentiated thyroid carcinoma and compensate for the underestimation of survival in patients with very poor prognosis. PATIENTS AND

methodsPatient data were collected from the Surveillance, Epidemiological, and End Result (SEER) data resource from 2010 to 2019. Multivariate analysis was carried out by the Cox proportional hazards regression to construct a nomogram. Receiver operating characteristic (ROC) curves along with calibration were employed to assess the effectiveness of the model.The life table was used to estimate the conditional cancer-specific survival (CSS).

resultsIn the training set, the AUCs for the CSS nomogram were 0.728, 0.741, and 0.779, with a c-index of 0.682, indicating good predictive performance at 3, 5, and 10 years. In the validation set, the AUCs for the CSS nomogram were 0.706, 0.726, and 0.769, with a c-index of 0.696, while the AUCs for the 8th TNM staging system were 0.521, 0.555, and 0.601, with a c-index of 0.579. The overall 5-year conditional survival rate for patients increased slightly from 63.44 to 70.52%. The survival gap was greatest between patients aged <55 years and those aged ≥55 years.

conclusionWe established a nomogram combined with dynamic survival analysis, which serve as promising options for prognosis estimation, to enhance personalized evaluation of survival risks and provide the basis for the development of more clinical treatment approaches.

Indexed as

Lung NeoplasmsThyroid NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedNomogramsPrognosisSEER ProgramSurvival AnalysisSurvival RateYoung AdultCancer-specific survivalConditional survivalNomogramPulmonary metastasesThyroidcancer

Identifiers

PMID39589684

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