Evidence map›Paper›PMID 39589662›Full record

ArticleInternational journal of implant dentistry2024

Brain-derived neurotrophic factor promotes bone regeneration in a canine model of peri-implantitis.

Shoko Kono, Shinya Sasaki, Shinji Matsuda, Katsuhiro Takeda, Tomoyuki Iwata, Kazuhisa Ouhara, Mikihito Kajiya, Hidemi Kurihara, Noriyoshi Mizuno

Abstract read
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In one paragraph

Article in International journal of implant dentistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shoko KonoDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
Shinya SasakiDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan. sdf6936@hiroshima-u.ac.jp.
Shinji MatsudaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
Katsuhiro TakedaDepartment of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Tomoyuki IwataDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
Kazuhisa OuharaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
Mikihito KajiyaCenter of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan.
Hidemi KuriharaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
Noriyoshi MizunoDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.

Funding

JSPS KAKENHI JP20K18574JST SPRING JPMJSP2132
6 · The paper itself

Abstract

purposeThe present study aims to determine whether the brain-derived neurotrophic factor (BDNF)/high-molecular-weight hyaluronic acid (HMW-HA) complex could regenerate bone around implants lost due to peri-implantitis.

methodsDogs had their three premolars extracted, and three implants were placed on each side. After osseointegration, 3-0 silk threads were ligated around the healing abutment for 12 weeks. Implants were classified into four groups-no treatment (control group), non-surgical debridement (debridement group), non-surgical debridement with application of HMW-HA (HMW-HA group), and non-surgical debridement with application of BDNF/HMW-HA complex (BDNF/HMW-HA group). Probing pocket depth (PPD), attachment level (AL), and bleeding on probing (BOP) were recorded before and 12 weeks after each treatment. Standardized intraoral radiographs were obtained, and histological analysis was conducted.

resultsThe bone level on radiographs significantly improved (median -0.15 mm, IQR -0.31 to 0.10) only in the BDNF/HMW-HA group, while changes in PPD and AL were similar to those in other groups. The BOP positivity rate decreased in the debridement and BDNF/HMW-HA groups. Unlike images of the other groups, histological images of the BDNF/HMW-HA group showed no epithelial migration toward the tip of the implant. Inflammatory cell infiltration was reduced compared with that in the other groups. New bone was observed around the implants only in the BDNF/HMW-HA group.

conclusionsThe BDNF/HMW-HA complex appears to promote bone regeneration when combined with non-surgical debridement for peri-implantitis.

Indexed as

Bone RegenerationBrain-Derived Neurotrophic FactorDisease Models, AnimalPeri-ImplantitisAnimalsDebridementDogsHyaluronic AcidOsseointegrationBrain-Derived Neurotrophic FactorHyaluronic AcidBDNFBone regenerationCanine modelPeri-implantitisReosseointegration

Identifiers

PMID39589662
PMCPMC11599645

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.