Evidence map›Paper›PMID 39589414›Full record

ArticleEJNMMI radiopharmacy and chemistry2024

Preclinical evaluation and automated synthesis of [

Asif Noor, Emily R McGowan, Jessica K Van Zuylekom, Carleen Cullinane, Peter D Roselt, Rodney J Hicks, Michael P Wheatcroft, Paul S Donnelly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Asif NoorSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia. asif.noor@unimelb.edu.au.
Emily R McGowanSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.
Jessica K Van ZuylekomResearch Division, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
Carleen CullinaneResearch Division, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
Peter D RoseltSir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.
Rodney J HicksResearch Division, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
Michael P WheatcroftTelix Pharmaceuticals Limited, Suite 401, 55 Flemington Road, North Melbourne, Melbourne, VIC, 3051, Australia.
Paul S DonnellySchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia. pauld@unimelb.edu.au.ORCID http://orcid.org/0000-0001-5373-0080

Funding

Australian Research Council Australian Research CouncilInnovative Manufacturing CRC Innovative Manufacturing CRCNational Health and Medical Research Council National Health and Medical Research Council
6 · The paper itself

Abstract

backgroundCarbonic Anhydrase IX (CAIX) is a zinc metalloenzyme that is over-expressed in many cancers making it a valid target for targeted diagnostic imaging with Positron Emission Tomography (PET). The monoclonal antibody girentuximab binds to CAIX and when radiolabelled with positron-emitting zirconium-89 can be used for diagnostic PET imaging of CAIX positive tumours.

resultsReaction of desferrioxamine squaramide ethyl ester with girentuximab allowed isolation of a conjugate with desferrioxamine squaramide (DFOSq) covalently attached to girentuximab through stable vinylogous amide linkages to give DFOSq-girentuximab. This conjugate was radiolabelled with zirconium-89 to give [

conclusions[

Indexed as

Automated synthesisCarbonic anhydrase IXDFO-squaramideGirentuximabRadiopharmaceuticalsZirconium-89Zirconium-89 labelled antibodies

Identifiers

PMID39589414
PMCPMC11599670

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.