ArticleCancer reports (Hoboken, N.J.)2024
Beyond the Surface: A Unique Presentation of Acute Promyelocytic Leukemia as Idiopathic Intracranial Hypertension: A Case Report.
Article in Cancer reports (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia defined by a fusion gene transcript called PML::RARA. Pseudotumor cerebri (PTC) is characterized by elevated intracranial pressure (ICP) and presents with pulsatile tinnitus, headaches, and visual disturbances. Pseudotumor cerebri has been observed in some patients undergoing long-term ATRA therapy. While both APL and PTC have been individually described in the literature, their coexistence in a single patient, especially with PTC being the first clinical manifestation of APL, is an exceptionally rare occurrence, making this case particularly unique and warranting further investigation. CASE PRESENTATION: We present the case of a 30-year-old woman who initially presented with symptoms suggestive of PTC. The diagnosis of PTC was confirmed through a lumbar puncture. However, further investigations revealed that the patient had APL, which is typically sensitive to treatment with all-trans-retinoic acid (ATRA). To our knowledge, the association between APL and PTC as the first clinical manifestation of APL in adult patients has not been previously reported in the literature, further highlighting the exceptional rarity of this case.
conclusionsThis case underscores the importance of considering underlying systemic diseases in patients presenting with PTC, as it may represent an exceptionally rare initial manifestation of a rare underlying malignancy such as APL. The coexistence of APL and PTC in this patient highlights the need for a comprehensive evaluation and management approach to promptly diagnose and treat coexisting conditions. Healthcare providers must be aware of this association and consider the possibility of APL when evaluating patients with PTC symptoms. Such awareness can prompt timely recognition and appropriate management, thereby improving patient outcomes and preventing potential delays in diagnosis and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.