ArticleThe Journal of infectious diseases2025
Genomic Analysis of Global Mycobacterium abscessus Isolates Reveals Ongoing Evolution of Drug Resistance-Associated Genes.
Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Expanding the scope of Mycobacterium abscessus reference strains to improve pulmonary disease modeling.Disease models & mechanisms · 2026Article
- Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.International journal of molecular sciences · 2026Review
- Novel Hawai'i and Pacific Island circulating clusters ofApplied and environmental microbiology · 2026Article
- Defining the Mechanism of Action and Resistance of NewACS chemical biology · 2026Article
- Comparative analysis of drug susceptibility among different Mycobacterium abscessus morphotypes.BMC microbiology · 2025Article
- Expanding the scope ofbioRxiv : the preprint server for biology · 2025Article
- Limited predictive power of known resistance genes for phenotypic drug resistance in clinicalAntimicrobial agents and chemotherapy · 2025Article
- Defining the mechanism of action of the nitrofuranyl piperazine HC2210 against Mycobacterium abscessus.npj antimicrobials and resistance · 2025Article
- Population genetic analysis of clinicalFrontiers in cellular and infection microbiology · 2024Article
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Authors and funding
17 authors.
Funding
Abstract
Mycobacterium abscessus (MAB) is intrinsically resistant to many antibiotics, but the evolution of acquired drug resistance is poorly understood. We analyzed published genomes of 5617 clinical MAB isolates from 20 countries and searched for signals of ongoing evolution in 35 drug resistance-associated genes. Of these, we found 14 genes that were subject to positive selection, and we identified novel mutational sites under selection. Among these, the erm(41) V80I mutation arose exclusively in strains with erm(41) 28T and affected 50.5% (1750/3465) of subsp abscessus isolates. The study provided evidence that MAB is evolving mutations in drug resistance-associated genes, and further research is needed to understand the functional consequences of these mutations.
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