Evidence map›Paper›PMID 39589129›Full record

ArticlemBio2025

Identification of determinants that allow maintenance of high-level fluoroquinolone resistance in

Efrat Hamami, Wenwen Huo, Juan Hernandez-Bird, Arnold Castaneda, Jinna Bai, Sapna Syal, Juan C Ortiz-Marquez, Tim van Opijnen, Edward Geisinger, Ralph R Isberg

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Virulence · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Efrat HamamiDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0009-0008-1950-3587
Wenwen HuoDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Juan Hernandez-BirdDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Arnold CastanedaDepartment of Biology, Tufts University, Medford, Massachusetts, USA.
Jinna BaiDepartment of Biology, Northeastern University, Boston, Massachusetts, USA.
Sapna SyalDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Juan C Ortiz-MarquezDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
Tim van OpijnenInnovation Laboratory, Broad Institute, Cambridge, Massachusetts, USA.
Edward GeisingerDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0001-9661-8072
Ralph R IsbergDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-8330-3554

Funding

Innovative technologies to transform antibiotic discovery. Project 4 Infection site-specific amplification of antimicrobial conjugatesU19AI142780 · NIAID · BROAD INSTITUTE, INC. · PI HUNG, DEBORAH T · 2019 to 2023
$33.9M
Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
Drug resistance enablers and their role in antibiotic treatment failureU19AI158076 · NIAID · BROAD INSTITUTE, INC. · PI COOPER, VAUGHN, ISBERG, RALPH R. · 2022 to 2025
$10.0M
MOLECULAR ANALYSIS OF MICROBIAL PATHOGENST32AI007422 · NIAID · TUFTS UNIVERSITY BOSTON · PI Ralph R. Isberg · 1992 to 2026
$5.7M
Global Circuitry that Controls Acinetobacter Resistance and VirulenceR01AI162996 · NIAID · NORTHEASTERN UNIVERSITY · PI GEISINGER, EDWARD · 2021 to 2025
$1.9M
High-Throughput DNA SequencerS10OD032203 · OD · TUFTS UNIVERSITY BOSTON · PI TAI, ALBERT K · 2022 to 2022
$804k
Identification of the Achilles’ heel in Acinetobacter fluoroquinolone-resistant mutantsR21AI128328 · NIAID · TUFTS UNIVERSITY BOSTON · PI ISBERG, RALPH R. · 2017 to 2018
$454k
NIAID NIH HHS R01 AI162996NIAID NIH HHS R21 AI128328NIAID NIH HHS T32 AI007422NIAID NIH HHS U01 AI124302NIAID NIH HHS U19 AI142780NIAID NIH HHS U19 AI158076NIH HHS S10 OD032203
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBacterial ProteinsDrug Resistance, BacterialFluoroquinolonesMembrane Transport ProteinsGene Expression Regulation, BacterialMicrobial Sensitivity TestsMutagenesis, InsertionalAnti-Bacterial AgentsBacterial ProteinsFluoroquinolonesMembrane Transport ProteinsAcinetobacterdrug resistance mechanismsefflux pumps

Identifiers

PMID39589129
PMCPMC11708032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.