ArticleMedicine and science in sports and exercise2025
Physical Activity Declines over a 12-Month Period in Parkinson's Disease: Considerations for Longitudinal Activity Monitoring.
Article in Medicine and science in sports and exercise, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04000360 (Pragmatic Cyclical Lower Extremity Exercise Trial for Parkinson's Disease), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pragmatic Cyclical Lower Extremity Exercise Trial for Parkinson's Disease
Who cites it
2 citing papers in PubMed.
- Creating and Evaluating a Prediction Equation for VO 2peak in Individuals with Early Stage, Never Medicated Parkinson's Disease.Medicine and science in sports and exercise · 2026Article
- Minimal Clinically Important Difference of Average Daily Steps Measured Through a Consumer Smartwatch in People With Mild-to-Moderate Parkinson Disease: Cross-Sectional Study.JMIR mHealth and uHealth · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeThe purpose of this project was to evaluate physical activity trends in individuals with Parkinson's disease (PD) over a 12-month period using continuous activity monitoring. Environmental (temperature) and cultural factors (represented by day of the week) were evaluated as potential external sources of variability. It was hypothesized that physical activity would decline over the course of 12 months. Further, it was hypothesized that participants would exhibit greater physical activity on warmer days and that the day of the week would have minimal impact on physical activity as many participants were no longer in the workforce.
methodsParticipants were part of the Usual and Customary Care arm ( N = 119) of the CYClical Lower Extremity Exercise Trial for Parkinson's disease-II (CYCLE-II) at the Cleveland Clinic and University of Utah. Participants wore a Garmin Vivofit4® device daily for 12 months. A linear mixed effects model was created to model daily steps over 12 months.
resultsParticipants wore their activity monitors on 93% of study days. Steps per day declined by 6.1% over 12 months (95% confidence interval, 12.6% decline, 0.9% increase; P = 0.09). Steps per day were greater with warmer temperatures ( P < 0.001), plateauing and declining between 75°F to 85°F (24-29°C). Participants took fewer steps on Sunday; this daily difference was more pronounced for Utah participants, who took 25% fewer steps on Sundays compared with other weekdays ( P < 0.001).
conclusionsMost individuals live with PD for decades, and interventions should address the expected annual decline in daily step count. Environmental and cultural factors impact daily step count and should be adjusted for in short- and long-term monitoring of physical activity in individuals with PD.
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Registered trials
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